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Proline, a privileged fragment in drug design: advances and future perspectives.

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Title: Proline, a privileged fragment in drug design: advances and future perspectives.
Authors: Li TT; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Liu LR; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Ge GH; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Guo S; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Zhang X; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Zhou XF; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Liu JY; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China., Liang JW; School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, China; Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, 571199, China. Electronic address: jwliang@muhn.edu.cn., Meng FH; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: fhmeng@cmu.edu.cn., Zhang TJ; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: tjzhang@cmu.edu.cn.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118685. Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Proline, a privileged fragment in drug design: advances and future perspectives.
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  Data: <searchLink fieldCode="AU" term="%22Li+TT%22">Li TT</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Liu+LR%22">Liu LR</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Ge+GH%22">Ge GH</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Guo+S%22">Guo S</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Zhou+XF%22">Zhou XF</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Liu+JY%22">Liu JY</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China.<br /><searchLink fieldCode="AU" term="%22Liang+JW%22">Liang JW</searchLink>; School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, China; Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou, Hainan, 571199, China. Electronic address: jwliang@muhn.edu.cn.<br /><searchLink fieldCode="AU" term="%22Meng+FH%22">Meng FH</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: fhmeng@cmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+TJ%22">Zhang TJ</searchLink>; School of Pharmacy / Key Laboratory of Research and Development of Small Molecule Targeted Antitumor Drugs, China Medical University, 77 Puhe Road, North New Area, Shenyang, 110122, China. Electronic address: tjzhang@cmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118685. <i>Date of Electronic Publication: </i>2026 Feb 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118685
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              Text: 2026 Apr 15
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