Disruption of the human cystin-1 myristoyl-electrostatic switch causes polycystic kidney disease that phenocopies autosomal recessive polycystic kidney disease.
Saved in:
| Title: | Disruption of the human cystin-1 myristoyl-electrostatic switch causes polycystic kidney disease that phenocopies autosomal recessive polycystic kidney disease. |
|---|---|
| Authors: | Yang C; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA., Harafuji N; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA., Watts JA; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA., Tao B; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Moran C; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA., Clements J; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA., Price K; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA., Laucevicius A; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA., Burrill N; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Gebb J; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Soni S; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Oliver E; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Savla JJ; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Christ L; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Moldenhauer J; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Hartung EA; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Didier R; Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA., Santani A; Veritas Genetics, Danvers, Massachusetts, USA., Sandford RN; Academic Department of Genomic Medicine, University of Cambridge, Cambridge, UK., Selkirk L; Luton and Dunstable University Hospital, Lutton, UK., Radley JA; North West Thames Regional Genetics Service, London, UK., Mann K; East Genomic Laboratory Hub, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK., Simonicova I; East Genomic Laboratory Hub, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK., Karl R; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Kariat Ashraf AP; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Wachten D; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Wilson L; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Targeted Metabolomics and Proteomics Laboratory, University of Alabama at Birmingham, Birmingham, Alabama, USA., Bebok Z; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA., Caldovic L; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA., Guay-Woodford LM; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Electronic address: guaywoodfl@chop.edu. |
| Source: | Kidney international [Kidney Int] 2026 May; Vol. 109 (5), pp. 939-956. Date of Electronic Publication: 2026 Feb 18. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41720266 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Disruption of the human cystin-1 myristoyl-electrostatic switch causes polycystic kidney disease that phenocopies autosomal recessive polycystic kidney disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Harafuji+N%22">Harafuji N</searchLink>; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Watts+JA%22">Watts JA</searchLink>; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Tao+B%22">Tao B</searchLink>; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Moran+C%22">Moran C</searchLink>; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Clements+J%22">Clements J</searchLink>; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Price+K%22">Price K</searchLink>; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Laucevicius+A%22">Laucevicius A</searchLink>; Integrated Biomedical Sciences Program, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Burrill+N%22">Burrill N</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gebb+J%22">Gebb J</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Soni+S%22">Soni S</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Oliver+E%22">Oliver E</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Savla+JJ%22">Savla JJ</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Christ+L%22">Christ L</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Moldenhauer+J%22">Moldenhauer J</searchLink>; Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Hartung+EA%22">Hartung EA</searchLink>; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Didier+R%22">Didier R</searchLink>; Department of Radiology, Boston Children's Hospital, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Santani+A%22">Santani A</searchLink>; Veritas Genetics, Danvers, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sandford+RN%22">Sandford RN</searchLink>; Academic Department of Genomic Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Selkirk+L%22">Selkirk L</searchLink>; Luton and Dunstable University Hospital, Lutton, UK.<br /><searchLink fieldCode="AU" term="%22Radley+JA%22">Radley JA</searchLink>; North West Thames Regional Genetics Service, London, UK.<br /><searchLink fieldCode="AU" term="%22Mann+K%22">Mann K</searchLink>; East Genomic Laboratory Hub, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simonicova+I%22">Simonicova I</searchLink>; East Genomic Laboratory Hub, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Karl+R%22">Karl R</searchLink>; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kariat+Ashraf+AP%22">Kariat Ashraf AP</searchLink>; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wachten+D%22">Wachten D</searchLink>; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Wilson+L%22">Wilson L</searchLink>; Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Targeted Metabolomics and Proteomics Laboratory, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Bebok+Z%22">Bebok Z</searchLink>; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Caldovic+L%22">Caldovic L</searchLink>; Center for Precision Medicine and Genomics Research, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA.<br /><searchLink fieldCode="AU" term="%22Guay-Woodford+LM%22">Guay-Woodford LM</searchLink>; Center for Translational Science, Children's National Research Institute, Children's National Hospital, Washington, District of Columbia, USA; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. Electronic address: guaywoodfl@chop.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220323470%22">Kidney international</searchLink> [Kidney Int] 2026 May; Vol. 109 (5), pp. 939-956. <i>Date of Electronic Publication: </i>2026 Feb 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0323470 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-1755 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200852538%22">00852538 </searchLink><i>NLM ISO Abbreviation: </i>Kidney Int <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41720266 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.kint.2026.01.023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 939 Titles: – TitleFull: Disruption of the human cystin-1 myristoyl-electrostatic switch causes polycystic kidney disease that phenocopies autosomal recessive polycystic kidney disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yang C – PersonEntity: Name: NameFull: Harafuji N – PersonEntity: Name: NameFull: Watts JA – PersonEntity: Name: NameFull: Tao B – PersonEntity: Name: NameFull: Moran C – PersonEntity: Name: NameFull: Clements J – PersonEntity: Name: NameFull: Price K – PersonEntity: Name: NameFull: Laucevicius A – PersonEntity: Name: NameFull: Burrill N – PersonEntity: Name: NameFull: Gebb J – PersonEntity: Name: NameFull: Soni S – PersonEntity: Name: NameFull: Oliver E – PersonEntity: Name: NameFull: Savla JJ – PersonEntity: Name: NameFull: Christ L – PersonEntity: Name: NameFull: Moldenhauer J – PersonEntity: Name: NameFull: Hartung EA – PersonEntity: Name: NameFull: Didier R – PersonEntity: Name: NameFull: Santani A – PersonEntity: Name: NameFull: Sandford RN – PersonEntity: Name: NameFull: Selkirk L – PersonEntity: Name: NameFull: Radley JA – PersonEntity: Name: NameFull: Mann K – PersonEntity: Name: NameFull: Simonicova I – PersonEntity: Name: NameFull: Karl R – PersonEntity: Name: NameFull: Kariat Ashraf AP – PersonEntity: Name: NameFull: Wachten D – PersonEntity: Name: NameFull: Wilson L – PersonEntity: Name: NameFull: Bebok Z – PersonEntity: Name: NameFull: Caldovic L – PersonEntity: Name: NameFull: Guay-Woodford LM IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1523-1755 Numbering: – Type: volume Value: 109 – Type: issue Value: 5 Titles: – TitleFull: Kidney international Type: main |
| ResultId | 1 |
