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Efficacy and harms of polypills for cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials.

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Title: Efficacy and harms of polypills for cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials.
Authors: Portela BM; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA., Shan RM; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA., Miriyapalli L; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA., Pasupuleti V; Oxford PharmaGenesis, Inc, Newtown, PA 18940, USA., Diaz-Arocutipa C; Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima 15024, Peru., Hernandez AV; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA; Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima 15024, Peru. Electronic address: adrian.hernandez-diaz@uconn.edu.
Source: European journal of internal medicine [Eur J Intern Med] 2026 May; Vol. 147, pp. 106775. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9003220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0828 (Electronic) Linking ISSN: 09536205 NLM ISO Abbreviation: Eur J Intern Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Portela+BM%22">Portela BM</searchLink>; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Shan+RM%22">Shan RM</searchLink>; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Miriyapalli+L%22">Miriyapalli L</searchLink>; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA.<br /><searchLink fieldCode="AU" term="%22Pasupuleti+V%22">Pasupuleti V</searchLink>; Oxford PharmaGenesis, Inc, Newtown, PA 18940, USA.<br /><searchLink fieldCode="AU" term="%22Diaz-Arocutipa+C%22">Diaz-Arocutipa C</searchLink>; Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima 15024, Peru.<br /><searchLink fieldCode="AU" term="%22Hernandez+AV%22">Hernandez AV</searchLink>; Health Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT 06269, USA; Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola (USIL), Lima 15024, Peru. Electronic address: adrian.hernandez-diaz@uconn.edu.
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  Data: <searchLink fieldCode="JN" term="%229003220%22">European journal of internal medicine</searchLink> [Eur J Intern Med] 2026 May; Vol. 147, pp. 106775. <i>Date of Electronic Publication: </i>2026 Feb 19.
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              Text: 2026 May
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