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Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.

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Title: Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties.
Authors: Kaivola J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Punovuori K; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Chastney MR; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Abdo H; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy., Follain G; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.; Turku Collegium for Science, Medicine and Technology (TCSMT), Turku, Finland., Mathieu M; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Joshi O; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Miroshnikova YA; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Krautgasser F; Faculty of Physics, University of Vienna, Vienna, Austria., Di Franco J; Faculty of Physics, University of Vienna, Vienna, Austria.; Vienna Doctoral School in Physics, University of Vienna, Vienna, Austria., Conway JRW; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Held S; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Bertillot F; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Hagström J; Department of Oral Pathology and Radiology, Dental Institute, University of Turku and Turku University Hospital, Turku, Finland.; Translational Cancer Research Unit, University of Helsinki, Helsinki, Finland., Mäkitie A; Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden., Irjala H; Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland., Ventelä S; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland., Hamidi H; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland., Scita G; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy., Cerbino R; Faculty of Physics, University of Vienna, Vienna, Austria., Wickström SA; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland., Ivaska J; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. joivaska@utu.fi.; Department of Life Technologies, University of Turku, Turku, Finland. joivaska@utu.fi.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland. joivaska@utu.fi.; Foundation for the Finnish Cancer Institute, Helsinki, Finland. joivaska@utu.fi.; Western Finnish Cancer Center (FICAN West), University of Turku, Turku, Finland. joivaska@utu.fi.
Source: Nature materials [Nat Mater] 2026 May; Vol. 25 (5), pp. 868-882. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101155473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4660 (Electronic) Linking ISSN: 14761122 NLM ISO Abbreviation: Nat Mater Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Kaivola+J%22">Kaivola J</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Punovuori+K%22">Punovuori K</searchLink>; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Chastney+MR%22">Chastney MR</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Abdo+H%22">Abdo H</searchLink>; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Follain+G%22">Follain G</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.; Turku Collegium for Science, Medicine and Technology (TCSMT), Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Mathieu+M%22">Mathieu M</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Joshi+O%22">Joshi O</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Miroshnikova+YA%22">Miroshnikova YA</searchLink>; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Krautgasser+F%22">Krautgasser F</searchLink>; Faculty of Physics, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Di+Franco+J%22">Di Franco J</searchLink>; Faculty of Physics, University of Vienna, Vienna, Austria.; Vienna Doctoral School in Physics, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Conway+JRW%22">Conway JRW</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Held+S%22">Held S</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Bertillot+F%22">Bertillot F</searchLink>; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Hagström+J%22">Hagström J</searchLink>; Department of Oral Pathology and Radiology, Dental Institute, University of Turku and Turku University Hospital, Turku, Finland.; Translational Cancer Research Unit, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Mäkitie+A%22">Mäkitie A</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Irjala+H%22">Irjala H</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Ventelä+S%22">Ventelä S</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.; Department of Otorhinolaryngology-Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Hamidi+H%22">Hamidi H</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.<br /><searchLink fieldCode="AU" term="%22Scita+G%22">Scita G</searchLink>; IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cerbino+R%22">Cerbino R</searchLink>; Faculty of Physics, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wickström+SA%22">Wickström SA</searchLink>; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.; Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ivaska+J%22">Ivaska J</searchLink>; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. joivaska@utu.fi.; Department of Life Technologies, University of Turku, Turku, Finland. joivaska@utu.fi.; InFLAMES Research Flagship Center, University of Turku, Turku, Finland. joivaska@utu.fi.; Foundation for the Finnish Cancer Institute, Helsinki, Finland. joivaska@utu.fi.; Western Finnish Cancer Center (FICAN West), University of Turku, Turku, Finland. joivaska@utu.fi.
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  Data: <searchLink fieldCode="JN" term="%22101155473%22">Nature materials</searchLink> [Nat Mater] 2026 May; Vol. 25 (5), pp. 868-882. <i>Date of Electronic Publication: </i>2026 Feb 20.
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