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A phase I/II clinical trial of neoadjuvant docetaxel/oxaliplatin/S‑1 (DOS) combination therapy for gastroesophageal junction adenocarcinoma.

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Title: A phase I/II clinical trial of neoadjuvant docetaxel/oxaliplatin/S‑1 (DOS) combination therapy for gastroesophageal junction adenocarcinoma.
Authors: Kumagai K; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. kumagai.koshi@kitasato-u.ac.jp., Hosoda K; Department of Surgery, Shonan Kamakura General Hospital, Kamakura, Japan., Katada C; Department of Medical Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ishido K; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan., Watanabe A; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan., Wada T; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan., Niihara M; Department of Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan., Higuchi T; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Sakuraya M; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Washio M; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Chuman M; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Harada H; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Fujita S; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Okuno K; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan., Yamashita K; Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan., Kumamoto Y; Department of General-Pediatric Hepato Biliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Naitoh T; Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan., Kusano C; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan., Hiki N; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
Source: Journal of gastroenterology [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 536-546. Date of Electronic Publication: 2026 Feb 21.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I
Journal Info: Publisher: Springer International Country of Publication: Japan NLM ID: 9430794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-5922 (Electronic) Linking ISSN: 09441174 NLM ISO Abbreviation: J Gastroenterol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase I/II clinical trial of neoadjuvant docetaxel/oxaliplatin/S‑1 (DOS) combination therapy for gastroesophageal junction adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Kumagai+K%22">Kumagai K</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan. kumagai.koshi@kitasato-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Hosoda+K%22">Hosoda K</searchLink>; Department of Surgery, Shonan Kamakura General Hospital, Kamakura, Japan.<br /><searchLink fieldCode="AU" term="%22Katada+C%22">Katada C</searchLink>; Department of Medical Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ishido+K%22">Ishido K</searchLink>; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+A%22">Watanabe A</searchLink>; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+T%22">Wada T</searchLink>; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Niihara+M%22">Niihara M</searchLink>; Department of Surgery, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Higuchi+T%22">Higuchi T</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Sakuraya+M%22">Sakuraya M</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Washio+M%22">Washio M</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Chuman+M%22">Chuman M</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Harada+H%22">Harada H</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Fujita+S%22">Fujita S</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Okuno+K%22">Okuno K</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.<br /><searchLink fieldCode="AU" term="%22Yamashita+K%22">Yamashita K</searchLink>; Division of Advanced Surgical Oncology, Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Kumamoto+Y%22">Kumamoto Y</searchLink>; Department of General-Pediatric Hepato Biliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Naitoh+T%22">Naitoh T</searchLink>; Department of Lower Gastrointestinal Surgery, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Kusano+C%22">Kusano C</searchLink>; Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Hiki+N%22">Hiki N</searchLink>; Department of Upper Gastrointestinal Surgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.
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  Data: <searchLink fieldCode="JN" term="%229430794%22">Journal of gastroenterology</searchLink> [J Gastroenterol] 2026 May; Vol. 61 (5), pp. 536-546. <i>Date of Electronic Publication: </i>2026 Feb 21.
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  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International%22">Springer International </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9430794 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1435-5922 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209441174%22">09441174 </searchLink><i>NLM ISO Abbreviation: </i>J Gastroenterol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00535-026-02366-9
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        Text: English
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        StartPage: 536
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      – TitleFull: A phase I/II clinical trial of neoadjuvant docetaxel/oxaliplatin/S‑1 (DOS) combination therapy for gastroesophageal junction adenocarcinoma.
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              Text: 2026 May
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