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Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system.

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Title: Changes in the 6th edition of the World Health Organization classification of tumours of the digestive system.
Authors: Arends MJ; Edinburgh Pathology, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK., Esposito I; Institute of Pathology, Heinrich Heine University and University Hospital of Dusseldorf, Düsseldorf, Germany., Gill AJ; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital St Leonards, Sydney, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia., Hruban RH; Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Khoury JD; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA., Kojima M; Department of Surgical Pathology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan., Montgomery EA; Department of Pathology, University of Miami Miller School of Medicine, Miami Beach, Florida, USA., Abdulkareem F; Department of Anatomic & Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria., Carneiro F; Ipatimup/i3S, Faculdade de Medicina da Universidade do Porto and Unidade Local de Saúde São João, Porto, Portugal., Costamagna G; Centre of Excellence of Gastrointestinal and Endocrine Metabolic Diseases, Ospedale Isola Tiberina - Gemelli, Rome, Italy., Lauwers G; Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., Polydorides AD; Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Rindi G; Section of Anatomic Pathology, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore - Unit of Anatomic Pathology, Department of Laboratory and Hematological Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Rugge M; Pathology and Cytopathology Unit, University of Padova, Padova, Italy., Schirmacher P; Institute of Pathology, University Hospital, Heidelberg University, Heidelberg, Germany., Srivastava A; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Yao J; Gastrointestinal Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA., Hodge JC; Department of Medical and Molecular Genetics, and IU Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA., Kench JG; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Camperdown, New South Wales, Australia., Rekhi B; Department of Pathology, Tata Memorial Centre, Mumbai, India., Reyes-Múgica M; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA., Sepulveda AR; Department of Pathology, George Washington University, School of Medicine and Health Sciences, Washington, DC, USA., Shi C; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA., Puspanathan P; International Agency for Research on Cancer, World Health Organisation, Lyon, France., Wijesinghe H; International Agency for Research on Cancer, World Health Organisation, Lyon, France., Giesen C; International Agency for Research on Cancer, World Health Organisation, Lyon, France., Ruiz BII; International Agency for Research on Cancer, World Health Organisation, Lyon, France., Lokuhetty D; International Agency for Research on Cancer, World Health Organisation, Lyon, France., Nagtegaal ID; Department of Pathology, Radboudumc, Nijmegen, the Netherlands.
Corporate Authors: WCT standing editorial board; International Agency for Research on Cancer, World Health Organisation, Lyon, France.
Source: Histopathology [Histopathology] 2026 Jun; Vol. 88 (7), pp. 1295-1314. Date of Electronic Publication: 2026 Feb 22.
Publication Type: Journal Article; Review
Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Arends+MJ%22">Arends MJ</searchLink>; Edinburgh Pathology, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Esposito+I%22">Esposito I</searchLink>; Institute of Pathology, Heinrich Heine University and University Hospital of Dusseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Gill+AJ%22">Gill AJ</searchLink>; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital St Leonards, Sydney, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Hruban+RH%22">Hruban RH</searchLink>; Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Khoury+JD%22">Khoury JD</searchLink>; Department of Pathology, Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, Nebraska, USA.<br /><searchLink fieldCode="AU" term="%22Kojima+M%22">Kojima M</searchLink>; Department of Surgical Pathology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Montgomery+EA%22">Montgomery EA</searchLink>; Department of Pathology, University of Miami Miller School of Medicine, Miami Beach, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Abdulkareem+F%22">Abdulkareem F</searchLink>; Department of Anatomic & Molecular Pathology, College of Medicine, University of Lagos, Lagos, Nigeria.<br /><searchLink fieldCode="AU" term="%22Carneiro+F%22">Carneiro F</searchLink>; Ipatimup/i3S, Faculdade de Medicina da Universidade do Porto and Unidade Local de Saúde São João, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Costamagna+G%22">Costamagna G</searchLink>; Centre of Excellence of Gastrointestinal and Endocrine Metabolic Diseases, Ospedale Isola Tiberina - Gemelli, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lauwers+G%22">Lauwers G</searchLink>; Department of Pathology, H. 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Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Hodge+JC%22">Hodge JC</searchLink>; Department of Medical and Molecular Genetics, and IU Simon Comprehensive Cancer Center, Indiana University, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Kench+JG%22">Kench JG</searchLink>; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, NSW Health Pathology, Camperdown, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Rekhi+B%22">Rekhi B</searchLink>; Department of Pathology, Tata Memorial Centre, Mumbai, India.<br /><searchLink fieldCode="AU" term="%22Reyes-Múgica+M%22">Reyes-Múgica M</searchLink>; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Sepulveda+AR%22">Sepulveda AR</searchLink>; Department of Pathology, George Washington University, School of Medicine and Health Sciences, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Shi+C%22">Shi C</searchLink>; Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Puspanathan+P%22">Puspanathan P</searchLink>; International Agency for Research on Cancer, World Health Organisation, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Wijesinghe+H%22">Wijesinghe H</searchLink>; International Agency for Research on Cancer, World Health Organisation, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Giesen+C%22">Giesen C</searchLink>; International Agency for Research on Cancer, World Health Organisation, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Ruiz+BII%22">Ruiz BII</searchLink>; International Agency for Research on Cancer, World Health Organisation, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Lokuhetty+D%22">Lokuhetty D</searchLink>; International Agency for Research on Cancer, World Health Organisation, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Nagtegaal+ID%22">Nagtegaal ID</searchLink>; Department of Pathology, Radboudumc, Nijmegen, the Netherlands.
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