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Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.

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Title: Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.
Authors: Cunha C; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark., Garcia-Ureña M; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark., Martínez R; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark., Romero-Lado MJ; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark., Fernandez MV; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain., Andreassen OA; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway., Sims R; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK., Tsolaki M; Aristotle University of Thessaloniki, Greece., Sleegers K; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland., Nicolas G; Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, Rouen, France., Sánchez-Juan P; Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada., Giedraitis V; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Holstege H; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam.; Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; VIB Center for Brain and Disease Research, ON5 Herestraat 49 - box 602, 3000 Leuven, Belgium, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium., van Duijn C; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, UK., van der Lee S; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands., Ramirez A; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; CECAD., Bellenguez C; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Lambert JC; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France., Frikke-Schmidt R; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark., Kilpeläinen TO; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.
Corporate Authors: EADB
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 17. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41728290
AccessLevel: 2
PubType: Academic Journal
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  Data: Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights.
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  Data: <searchLink fieldCode="AU" term="%22Cunha+C%22">Cunha C</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Garcia-Ureña+M%22">Garcia-Ureña M</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Martínez+R%22">Martínez R</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Romero-Lado+MJ%22">Romero-Lado MJ</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Fernandez+MV%22">Fernandez MV</searchLink>; Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental disorders, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Sims+R%22">Sims R</searchLink>; Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK.<br /><searchLink fieldCode="AU" term="%22Tsolaki+M%22">Tsolaki M</searchLink>; Aristotle University of Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Sleegers+K%22">Sleegers K</searchLink>; VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.<br /><searchLink fieldCode="AU" term="%22Hiltunen+M%22">Hiltunen M</searchLink>; Institute of Biomedicine, University of Eastern Finland, Yliopistoranta 1E, 70211 Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Nicolas+G%22">Nicolas G</searchLink>; Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Sánchez-Juan+P%22">Sánchez-Juan P</searchLink>; Alzheimer's Centre Reina Sofia-CIEN Foundation, Madrid, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ingelsson+M%22">Ingelsson M</searchLink>; Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Giedraitis+V%22">Giedraitis V</searchLink>; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ghidoni+R%22">Ghidoni R</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Holstege+H%22">Holstege H</searchLink>; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam.; Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.; VIB Center for Brain and Disease Research, ON5 Herestraat 49 - box 602, 3000 Leuven, Belgium, Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22van+Duijn+C%22">van Duijn C</searchLink>; Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands.; Nuffield Department of Population Health Oxford University, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22van+der+Lee+S%22">van der Lee S</searchLink>; Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam.; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ramirez+A%22">Ramirez A</searchLink>; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Department for Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.; Department of Psychiatry & Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA.; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.; CECAD.<br /><searchLink fieldCode="AU" term="%22Bellenguez+C%22">Bellenguez C</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Lambert+JC%22">Lambert JC</searchLink>; Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Frikke-Schmidt+R%22">Frikke-Schmidt R</searchLink>; Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kilpeläinen+TO%22">Kilpeläinen TO</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark.
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