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New approaches to uncover COPD pathobiology and develop therapies.

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Title: New approaches to uncover COPD pathobiology and develop therapies.
Authors: Tesfaigzi Y; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA., Yildirim AÖ; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilian's University, Munich, Germany.; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey., Polverino F; Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA., Conlon TM; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany., Sidhaye V; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Sauler M; Division of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Raju SV; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Jurkowska RZ; Division of Biomedicine, School of Biosciences, Cardiff University, Cardiff, United Kingdom., Chandra D; Division of Pulmonary, Allergy, Sleep and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Cho MH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Silverman EK; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Sun RC; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA., Castaldi P; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Tata PR; Departments of Cell Biology and Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Benam KH; Department of Medicine, Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Antony L; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA., Lehmann M; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.; Lung Aging and Regeneration, Institute for Lung Health (ILH), Giessen, Germany.; Institute for Lung Research, Philipps-University Marburg, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany., Kosmider B; Department of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA., Bahmed K; Department of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA., Negasi ZH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA., Bankoti K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA., Swaby C; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Department of Cell Biology, and., Lagowala DA; Department of Environmental Health and Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vural Y; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Division of Pulmonary, Allergy, Sleep and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Bayram H; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Department of Cellular and Molecular Medicine, Graduate School of Health Sciences, and.; Department of Pulmonary Medicine, School of Medicine, Koc University, Istanbul, Turkey., Faner R; Biomedicine Department, University of Barcelona, IDIBAPS, CIBER, Barcelona, Spain., Washko G; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA., Bui DS; Center for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia., Celli B; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA., Wasnick RM; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany., Neptune E; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Source: JCI insight [JCI Insight] 2026 Feb 23; Vol. 11 (4). Date of Electronic Publication: 2026 Feb 23 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Tesfaigzi+Y%22">Tesfaigzi Y</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Yildirim+AÖ%22">Yildirim AÖ</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilian's University, Munich, Germany.; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Polverino+F%22">Polverino F</searchLink>; Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Conlon+TM%22">Conlon TM</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Sidhaye+V%22">Sidhaye V</searchLink>; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Sauler+M%22">Sauler M</searchLink>; Division of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Raju+SV%22">Raju SV</searchLink>; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Jurkowska+RZ%22">Jurkowska RZ</searchLink>; Division of Biomedicine, School of Biosciences, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chandra+D%22">Chandra D</searchLink>; Division of Pulmonary, Allergy, Sleep and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Cho+MH%22">Cho MH</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+EK%22">Silverman EK</searchLink>; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sun+RC%22">Sun RC</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Castaldi+P%22">Castaldi P</searchLink>; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Tata+PR%22">Tata PR</searchLink>; Departments of Cell Biology and Medicine, Duke University School of Medicine, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Benam+KH%22">Benam KH</searchLink>; Department of Medicine, Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Antony+L%22">Antony L</searchLink>; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.<br /><searchLink fieldCode="AU" term="%22Lehmann+M%22">Lehmann M</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.; Lung Aging and Regeneration, Institute for Lung Health (ILH), Giessen, Germany.; Institute for Lung Research, Philipps-University Marburg, Universities of Giessen and Marburg Lung Center, German Center for Lung Research (DZL), Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kosmider+B%22">Kosmider B</searchLink>; Department of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bahmed+K%22">Bahmed K</searchLink>; Department of Microbiology, Immunology and Inflammation, Center for Inflammation and Lung Research, Temple University, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Negasi+ZH%22">Negasi ZH</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bankoti+K%22">Bankoti K</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Swaby+C%22">Swaby C</searchLink>; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Department of Cell Biology, and.<br /><searchLink fieldCode="AU" term="%22Lagowala+DA%22">Lagowala DA</searchLink>; Department of Environmental Health and Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Vural+Y%22">Vural Y</searchLink>; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Division of Pulmonary, Allergy, Sleep and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bayram+H%22">Bayram H</searchLink>; Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.; Department of Cellular and Molecular Medicine, Graduate School of Health Sciences, and.; Department of Pulmonary Medicine, School of Medicine, Koc University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Faner+R%22">Faner R</searchLink>; Biomedicine Department, University of Barcelona, IDIBAPS, CIBER, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Washko+G%22">Washko G</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Bui+DS%22">Bui DS</searchLink>; Center for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Celli+B%22">Celli B</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wasnick+RM%22">Wasnick RM</searchLink>; Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Neptune+E%22">Neptune E</searchLink>; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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