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Pentosidine accumulation induced by Akr1a deficiency drives aggression and hyperactivity.

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Title: Pentosidine accumulation induced by Akr1a deficiency drives aggression and hyperactivity.
Authors: Iino K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Igakuken Disease-oriented Molecular Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Toriumi K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Electronic address: toriumi-kz@igakuken.or.jp., Miyashita M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry, Takatsuki Clinic, Tokyo, Japan., Suzuki K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Community Mental Health, School of Medicine, Shinshu University, Nagano, Japan., Tabata K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Miyata S; Miyata Diabetes and Metabolism Clinic, Osaka, Japan., Takahashi M; Department of Biochemistry, Sapporo Medical University School of Medicine, Hokkaido, Japan., Fujii J; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan., Itokawa M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Arai M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Source: Neuroscience letters [Neurosci Lett] 2026 Apr 26; Vol. 877, pp. 138557. Date of Electronic Publication: 2026 Feb 21.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pentosidine accumulation induced by Akr1a deficiency drives aggression and hyperactivity.
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  Data: <searchLink fieldCode="AU" term="%22Iino+K%22">Iino K</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Igakuken Disease-oriented Molecular Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Toriumi+K%22">Toriumi K</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Electronic address: toriumi-kz@igakuken.or.jp.<br /><searchLink fieldCode="AU" term="%22Miyashita+M%22">Miyashita M</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry, Takatsuki Clinic, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Community Mental Health, School of Medicine, Shinshu University, Nagano, Japan.<br /><searchLink fieldCode="AU" term="%22Tabata+K%22">Tabata K</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Miyata+S%22">Miyata S</searchLink>; Miyata Diabetes and Metabolism Clinic, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takahashi+M%22">Takahashi M</searchLink>; Department of Biochemistry, Sapporo Medical University School of Medicine, Hokkaido, Japan.<br /><searchLink fieldCode="AU" term="%22Fujii+J%22">Fujii J</searchLink>; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan.<br /><searchLink fieldCode="AU" term="%22Itokawa+M%22">Itokawa M</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Arai+M%22">Arai M</searchLink>; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
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  Data: <searchLink fieldCode="JN" term="%227600130%22">Neuroscience letters</searchLink> [Neurosci Lett] 2026 Apr 26; Vol. 877, pp. 138557. <i>Date of Electronic Publication: </i>2026 Feb 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Scientific+Publishers+Ireland%22">Elsevier Scientific Publishers Ireland </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7600130 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7972 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203043940%22">03043940 </searchLink><i>NLM ISO Abbreviation: </i>Neurosci Lett <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.neulet.2026.138557
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      – Code: eng
        Text: English
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            – D: 26
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              Text: 2026 Apr 26
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              Y: 2026
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