Pentosidine accumulation induced by Akr1a deficiency drives aggression and hyperactivity.
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| Title: | Pentosidine accumulation induced by Akr1a deficiency drives aggression and hyperactivity. |
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| Authors: | Iino K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Igakuken Disease-oriented Molecular Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Toriumi K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. Electronic address: toriumi-kz@igakuken.or.jp., Miyashita M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry, Takatsuki Clinic, Tokyo, Japan., Suzuki K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Community Mental Health, School of Medicine, Shinshu University, Nagano, Japan., Tabata K; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan., Miyata S; Miyata Diabetes and Metabolism Clinic, Osaka, Japan., Takahashi M; Department of Biochemistry, Sapporo Medical University School of Medicine, Hokkaido, Japan., Fujii J; Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata, Japan., Itokawa M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Arai M; Schizophrenia Research Project, Department of Clinical Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan. |
| Source: | Neuroscience letters [Neurosci Lett] 2026 Apr 26; Vol. 877, pp. 138557. Date of Electronic Publication: 2026 Feb 21. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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