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β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights.

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Title: β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights.
Authors: Rashidi P; Cellular and Molecular research center, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran., Bagheri Z; Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Fars, Iran., Khodayar Z; Department of Biotechnology, Faculty of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran., Tarkashvand S; Sina Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Universal Scientific Education and Research Network (USERN), Tehran University of Medical Science, Tehran, Iran.; Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran., Elahirad N; Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran., Akhoondi R; Universal Scientific Education and Research Network (USERN), Tehran University of Medical Science, Tehran, Iran.; Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran., Moghaddam SH; School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran., Sanati M; Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran., Haghighatjou R; Research Center for Development of Nursing and Midwifery Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran., Yekani R; Department of Biochemistry and Biophysics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Mehboodi M; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Banimahdidehkordi A; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran., Rabiei S; Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Fars, Iran. r_saman22@hotmail.com., Dinvari H; Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. houra.dn@gmail.com., Maleki MH; Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. mhmlkteh@gmail.com.
Source: Clinical and experimental medicine [Clin Exp Med] 2026 Feb 24; Vol. 26 (1). Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: β-Hydroxybutyrate, a primary metabolite of ketogenic diets and its dual role in modulating colorectal cancer: from molecular mechanisms to therapeutic insights.
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  Data: <searchLink fieldCode="AU" term="%22Rashidi+P%22">Rashidi P</searchLink>; Cellular and Molecular research center, Ahvaz Jundishapur University of medical Sciences, Ahvaz, Iran.<br /><searchLink fieldCode="AU" term="%22Bagheri+Z%22">Bagheri Z</searchLink>; Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Fars, Iran.<br /><searchLink fieldCode="AU" term="%22Khodayar+Z%22">Khodayar Z</searchLink>; Department of Biotechnology, Faculty of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Tarkashvand+S%22">Tarkashvand S</searchLink>; Sina Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Universal Scientific Education and Research Network (USERN), Tehran University of Medical Science, Tehran, Iran.; Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Elahirad+N%22">Elahirad N</searchLink>; Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Akhoondi+R%22">Akhoondi R</searchLink>; Universal Scientific Education and Research Network (USERN), Tehran University of Medical Science, Tehran, Iran.; Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Moghaddam+SH%22">Moghaddam SH</searchLink>; School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.<br /><searchLink fieldCode="AU" term="%22Sanati+M%22">Sanati M</searchLink>; Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.<br /><searchLink fieldCode="AU" term="%22Haghighatjou+R%22">Haghighatjou R</searchLink>; Research Center for Development of Nursing and Midwifery Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran.<br /><searchLink fieldCode="AU" term="%22Yekani+R%22">Yekani R</searchLink>; Department of Biochemistry and Biophysics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Mehboodi+M%22">Mehboodi M</searchLink>; Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.<br /><searchLink fieldCode="AU" term="%22Banimahdidehkordi+A%22">Banimahdidehkordi A</searchLink>; Department of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.<br /><searchLink fieldCode="AU" term="%22Rabiei+S%22">Rabiei S</searchLink>; Clinical Research Development Unit, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Fars, Iran. r_saman22@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Dinvari+H%22">Dinvari H</searchLink>; Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran. houra.dn@gmail.com.<br /><searchLink fieldCode="AU" term="%22Maleki+MH%22">Maleki MH</searchLink>; Department of Clinical Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. mhmlkteh@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22100973405%22">Clinical and experimental medicine</searchLink> [Clin Exp Med] 2026 Feb 24; Vol. 26 (1). <i>Date of Electronic Publication: </i>2026 Feb 24.
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