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Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease.

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Title: Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease.
Authors: Bledsoe X; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wang TC; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wu Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Archer D; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Chen HH; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Naj AC; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bush WS; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Hohman TJ; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Dumitrescu L; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Below JE; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Gamazon ER; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71217.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Bledsoe+X%22">Bledsoe X</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wang+TC%22">Wang TC</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Archer+D%22">Archer D</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Chen+HH%22">Chen HH</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Naj+AC%22">Naj AC</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bush+WS%22">Bush WS</searchLink>; Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Hohman+TJ%22">Hohman TJ</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Dumitrescu+L%22">Dumitrescu L</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Below+JE%22">Below JE</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Gamazon+ER%22">Gamazon ER</searchLink>; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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  Data: <searchLink fieldCode="JN" term="%22101231978%22">Alzheimer's & dementia : the journal of the Alzheimer's Association</searchLink> [Alzheimers Dement] 2026 Feb; Vol. 22 (2), pp. e71217.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22John+Wiley+%26+Sons%2C+Ltd%22">John Wiley & Sons, Ltd </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101231978 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1552-5279 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215525260%22">15525260 </searchLink><i>NLM ISO Abbreviation: </i>Alzheimers Dement <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41732108
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        Value: 10.1002/alz.71217
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        Text: English
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            – D: 01
              M: 02
              Text: 2026 Feb
              Type: published
              Y: 2026
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