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Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data.

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Title: Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data.
Authors: Huneault HE; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. hhuneau@emory.edu.; Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA. hhuneau@emory.edu., Tiwari P; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; VA Healthcare System of Atlanta, Decatur, GA, USA., Jarrell ZR; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Smith MR; VA Healthcare System of Atlanta, Decatur, GA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Chen CY; Emory Integrated Metabolomics and Lipidomics Core, School of Medicine, Emory University, Atlanta, GA, USA., Ramirez Tovar A; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA., Sanchez-Torres C; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA., Gillespie S; Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA., Bai S; Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA., Carrillo-Larco RM; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Jain AK; Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA., Yates KP; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Neuschwander-Tetri BA; Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA., Schwimmer JB; Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA.; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA., Xanthakos SA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Molleston JP; Department of Pediatrics, Indiana University/Riley Hospital for Children, Indianapolis, IN, USA., Behling CA; Sharp Memorial Hospital, San Diego, California, USA., Fishbein MH; Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA., Hartman TJ; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, GA, USA., Pasquel FJ; Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Kamaleswaran R; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA., Jones DP; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Welsh JA; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.; Children's Healthcare of Atlanta, Atlanta, GA, USA., Vos MB; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.; Children's Healthcare of Atlanta, Atlanta, GA, USA.; Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA.
Source: Nature communications [Nat Commun] 2026 Feb 24; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data.
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  Data: <searchLink fieldCode="AU" term="%22Huneault+HE%22">Huneault HE</searchLink>; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. hhuneau@emory.edu.; Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA. hhuneau@emory.edu.<br /><searchLink fieldCode="AU" term="%22Tiwari+P%22">Tiwari P</searchLink>; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; VA Healthcare System of Atlanta, Decatur, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jarrell+ZR%22">Jarrell ZR</searchLink>; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+MR%22">Smith MR</searchLink>; VA Healthcare System of Atlanta, Decatur, GA, USA.; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Emory Integrated Metabolomics and Lipidomics Core, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ramirez+Tovar+A%22">Ramirez Tovar A</searchLink>; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sanchez-Torres+C%22">Sanchez-Torres C</searchLink>; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gillespie+S%22">Gillespie S</searchLink>; Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bai+S%22">Bai S</searchLink>; Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Carrillo-Larco+RM%22">Carrillo-Larco RM</searchLink>; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+AK%22">Jain AK</searchLink>; Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yates+KP%22">Yates KP</searchLink>; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Neuschwander-Tetri+BA%22">Neuschwander-Tetri BA</searchLink>; Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Schwimmer+JB%22">Schwimmer JB</searchLink>; Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA.; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xanthakos+SA%22">Xanthakos SA</searchLink>; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Molleston+JP%22">Molleston JP</searchLink>; Department of Pediatrics, Indiana University/Riley Hospital for Children, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Behling+CA%22">Behling CA</searchLink>; Sharp Memorial Hospital, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Fishbein+MH%22">Fishbein MH</searchLink>; Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Hartman+TJ%22">Hartman TJ</searchLink>; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Pasquel+FJ%22">Pasquel FJ</searchLink>; Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kamaleswaran+R%22">Kamaleswaran R</searchLink>; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.; Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Jones+DP%22">Jones DP</searchLink>; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Welsh+JA%22">Welsh JA</searchLink>; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.; Children's Healthcare of Atlanta, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Vos+MB%22">Vos MB</searchLink>; Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA.; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA.; Children's Healthcare of Atlanta, Atlanta, GA, USA.; Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Feb 24; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Feb 24.
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