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Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models.

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Title: Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models.
Authors: Orozco Morales ML; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; The Kids Research Institute Australia, Nedlands, WA, Australia., Lansley SM; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., Chin WL; The Kids Research Institute Australia, Nedlands, WA, Australia., Tilsed CM; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia., Principe N; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., Leslie C; Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia., Vitali BJ; The Kids Research Institute Australia, Nedlands, WA, Australia., Rwandamuriye FX; The Kids Research Institute Australia, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., de Jong E; The Kids Research Institute Australia, Nedlands, WA, Australia., Kidman J; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., Zemek RM; The Kids Research Institute Australia, Nedlands, WA, Australia., Rinaldi CA; Centre for Microscopy Characterisation and Analysis, Nedlands, WA, Australia., Lassmann T; The Kids Research Institute Australia, Nedlands, WA, Australia., Bosco A; Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA., Lee YCG; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.; Centre for Innovative Pleural Research, Sir Charles Gairdner Hospital, Nedlands, WA, Australia., Lake RA; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., Chee J; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia., Lesterhuis WJ; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia. willem.lesterhuis@uwa.edu.au.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia. willem.lesterhuis@uwa.edu.au.; The Kids Research Institute Australia, Nedlands, WA, Australia. willem.lesterhuis@uwa.edu.au.
Source: Scientific reports [Sci Rep] 2026 Feb 25; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Mesothelioma location influences the tumour microenvironment and immune checkpoint therapy response in preclinical models.
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  Data: <searchLink fieldCode="AU" term="%22Orozco+Morales+ML%22">Orozco Morales ML</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Lansley+SM%22">Lansley SM</searchLink>; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Chin+WL%22">Chin WL</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Tilsed+CM%22">Tilsed CM</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Principe+N%22">Principe N</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Leslie+C%22">Leslie C</searchLink>; Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Vitali+BJ%22">Vitali BJ</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Rwandamuriye+FX%22">Rwandamuriye FX</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22de+Jong+E%22">de Jong E</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Kidman+J%22">Kidman J</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Zemek+RM%22">Zemek RM</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Rinaldi+CA%22">Rinaldi CA</searchLink>; Centre for Microscopy Characterisation and Analysis, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Lassmann+T%22">Lassmann T</searchLink>; The Kids Research Institute Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Bosco+A%22">Bosco A</searchLink>; Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Lee+YCG%22">Lee YCG</searchLink>; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.; Centre for Innovative Pleural Research, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Lake+RA%22">Lake RA</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Chee+J%22">Chee J</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia.; Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Lesterhuis+WJ%22">Lesterhuis WJ</searchLink>; School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia. willem.lesterhuis@uwa.edu.au.; National Centre for Asbestos Related Diseases, Nedlands, WA, Australia. willem.lesterhuis@uwa.edu.au.; The Kids Research Institute Australia, Nedlands, WA, Australia. willem.lesterhuis@uwa.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Feb 25; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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