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PFKM governs metabolic shifts throughout skeletal muscle differentiation.

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Title: PFKM governs metabolic shifts throughout skeletal muscle differentiation.
Authors: Campos M; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Nguyen ST; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Kong X; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA., Yang Y; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Watson RL; Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gromova A; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA., Livelo CR; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Franco CN; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Cabral JE; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Seabrook LJ; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Dai S; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Liu Y; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Zhou M; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA., Hanse EA; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Sumigray K; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA., La Spada AR; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Neurology, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Seldin MM; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA., Plikus MV; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Nicholas DA; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., McNulty R; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Kong M; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA., Yokomori K; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA., Albrecht LV; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA. lvalbrec@uci.edu.; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA. lvalbrec@uci.edu.
Source: Nature metabolism [Nat Metab] 2026 Feb; Vol. 8 (2), pp. 489-505. Date of Electronic Publication: 2026 Feb 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: PFKM governs metabolic shifts throughout skeletal muscle differentiation.
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  Data: <searchLink fieldCode="AU" term="%22Campos+M%22">Campos M</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+ST%22">Nguyen ST</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+X%22">Kong X</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Watson+RL%22">Watson RL</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gromova+A%22">Gromova A</searchLink>; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Livelo+CR%22">Livelo CR</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Franco+CN%22">Franco CN</searchLink>; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cabral+JE%22">Cabral JE</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Seabrook+LJ%22">Seabrook LJ</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dai+S%22">Dai S</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hanse+EA%22">Hanse EA</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sumigray+K%22">Sumigray K</searchLink>; Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22La+Spada+AR%22">La Spada AR</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Neurology, School of Medicine, University of California, Irvine, Irvine, CA, USA.; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Seldin+MM%22">Seldin MM</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Plikus+MV%22">Plikus MV</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nicholas+DA%22">Nicholas DA</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22McNulty+R%22">McNulty R</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kong+M%22">Kong M</searchLink>; Department of Molecular Biology and Biochemistry, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yokomori+K%22">Yokomori K</searchLink>; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Albrecht+LV%22">Albrecht LV</searchLink>; Department of Developmental and Cell Biology, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA, USA. lvalbrec@uci.edu.; Department of Pharmaceutical Sciences, School of Pharmacology and Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA. lvalbrec@uci.edu.
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