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Direct reprogramming of Müller glia into photoreceptors via multiple transcription factors and small molecules: molecular mechanisms and transcriptomic analysis.

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Title: Direct reprogramming of Müller glia into photoreceptors via multiple transcription factors and small molecules: molecular mechanisms and transcriptomic analysis.
Authors: Endo Y; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Sugano E; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Seko Y; Sensory Functions Section, Research Institute, National Rehabilitation Center for Persons With Disabilities, 4-1 Namiki, Tokorozawa, 359-8555, Japan., Fukuda T; Laboratory of Cell Engineering and Molecular Genetics, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Tabata K; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Kakizaki T; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Maruoka S; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Yokoyama T; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Mori H; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Ozaki T; Laboratory of Cell Biochemistry, Department of Life Sciences, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate, 020-8550, Japan., Bai L; Laboratory of Cell Engineering and Molecular Genetics, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan., Tomita H; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan. htomita@iwate-u.ac.jp.
Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 2026 May; Vol. 62 (5), pp. 685-703. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-706X (Electronic) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Endo+Y%22">Endo Y</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Sugano+E%22">Sugano E</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Seko+Y%22">Seko Y</searchLink>; Sensory Functions Section, Research Institute, National Rehabilitation Center for Persons With Disabilities, 4-1 Namiki, Tokorozawa, 359-8555, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuda+T%22">Fukuda T</searchLink>; Laboratory of Cell Engineering and Molecular Genetics, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Tabata+K%22">Tabata K</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Kakizaki+T%22">Kakizaki T</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Maruoka+S%22">Maruoka S</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Yokoyama+T%22">Yokoyama T</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+H%22">Mori H</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Ozaki+T%22">Ozaki T</searchLink>; Laboratory of Cell Biochemistry, Department of Life Sciences, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate, 020-8550, Japan.<br /><searchLink fieldCode="AU" term="%22Bai+L%22">Bai L</searchLink>; Laboratory of Cell Engineering and Molecular Genetics, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan.<br /><searchLink fieldCode="AU" term="%22Tomita+H%22">Tomita H</searchLink>; Laboratory of Visual Neuroscience, Molecular Medical Science, Iwate University Division of Agriculture, 4-3-5 Ueda, Morioka, Iwate, 020-8551, Japan. htomita@iwate-u.ac.jp.
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        Value: 10.1007/s11626-026-01164-0
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              Text: 2026 May
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              Y: 2026
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