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Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection.

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Title: Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection.
Authors: Adeyinka OS; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Metibemu DS; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Hampton T; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Ojobor JC; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Crown O; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Falode J; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Barrera MD; Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, VA, 20109, USA., Alem F; Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, VA, 20109, USA., Narayanan A; Department of Biology, College of Science, George Mason University, Fairfax, VA, 22030, USA., Ogungbe IV; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA; Biomolecular Science, LLC, Huntsville, AL, 35899, USA. Electronic address: victor.ogungbe@uah.edu.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118696. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Broad-spectrum inhibitor of non-structural protein 2 protease shows therapeutic efficacy against Venezuelan equine encephalitis viral infection.
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  Data: <searchLink fieldCode="AU" term="%22Adeyinka+OS%22">Adeyinka OS</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Metibemu+DS%22">Metibemu DS</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Hampton+T%22">Hampton T</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Ojobor+JC%22">Ojobor JC</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Crown+O%22">Crown O</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Falode+J%22">Falode J</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Barrera+MD%22">Barrera MD</searchLink>; Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, VA, 20109, USA.<br /><searchLink fieldCode="AU" term="%22Alem+F%22">Alem F</searchLink>; Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, VA, 20109, USA.<br /><searchLink fieldCode="AU" term="%22Narayanan+A%22">Narayanan A</searchLink>; Department of Biology, College of Science, George Mason University, Fairfax, VA, 22030, USA.<br /><searchLink fieldCode="AU" term="%22Ogungbe+IV%22">Ogungbe IV</searchLink>; Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, AL, 35899, USA; Biomolecular Science, LLC, Huntsville, AL, 35899, USA. Electronic address: victor.ogungbe@uah.edu.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Apr 15; Vol. 308, pp. 118696. <i>Date of Electronic Publication: </i>2026 Feb 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejmech.2026.118696
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              Text: 2026 Apr 15
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