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Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.

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Title: Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.
Authors: Kacerova T; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK., Willemse E; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland., Oechtering J; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Radford-Smith DE; Department of Pharmacology, University of Oxford, Oxford, UK., Xiong W; Department of Pharmacology, University of Oxford, Oxford, UK., Sealey M; Department of Pharmacology, University of Oxford, Oxford, UK., Saldana L; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Maleska Maceski A; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Yeo T; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Lee Kong Chian School of Medicine (Nanyang Technological University), Singapore, Singapore.; A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore., DeLuca G; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Palace J; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Leppert D; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Kuhle J; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Anthony DC; Department of Pharmacology, University of Oxford, Oxford, UK. daniel.anthony@pharm.ox.ac.uk., Probert F; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Source: Communications medicine [Commun Med (Lond)] 2026 Feb 25; Vol. 6 (1). Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.
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  Data: <searchLink fieldCode="AU" term="%22Kacerova+T%22">Kacerova T</searchLink>; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Willemse+E%22">Willemse E</searchLink>; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.; Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Oechtering+J%22">Oechtering J</searchLink>; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Radford-Smith+DE%22">Radford-Smith DE</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Xiong+W%22">Xiong W</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Sealey+M%22">Sealey M</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Saldana+L%22">Saldana L</searchLink>; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maleska+Maceski+A%22">Maleska Maceski A</searchLink>; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Yeo+T%22">Yeo T</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.; Lee Kong Chian School of Medicine (Nanyang Technological University), Singapore, Singapore.; A*STAR Institute of Molecular and Cell Biology, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22DeLuca+G%22">DeLuca G</searchLink>; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Palace+J%22">Palace J</searchLink>; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Leppert+D%22">Leppert D</searchLink>; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kuhle+J%22">Kuhle J</searchLink>; Department of Neurology, University Hospital and University of Basel, Basel, Switzerland.; Multiple Sclerosis Centre, Departments of Biomedicine and Clinical Research, University Hospital and University of Basel, Basel, Switzerland.; Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Anthony+DC%22">Anthony DC</searchLink>; Department of Pharmacology, University of Oxford, Oxford, UK. daniel.anthony@pharm.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Probert+F%22">Probert F</searchLink>; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
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  Data: <searchLink fieldCode="JN" term="%229918250414506676%22">Communications medicine</searchLink> [Commun Med (Lond)] 2026 Feb 25; Vol. 6 (1). <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918250414506676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-664X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222730664X%22">2730664X </searchLink><i>NLM ISO Abbreviation: </i>Commun Med (Lond) <i>Subsets: </i>PubMed not MEDLINE
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