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Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.

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Title: Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
Authors: Campian JL; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Le SB; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Ghiaseddin A; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA., Butt OH; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Manektalia H; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Chen D; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Xu Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA., Liu J; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA., Rahman M; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA., Thai N; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Leidig WA; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA., Johanns T; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Ansstas G; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Zhou AY; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Pugazenthi S; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA., Dunn GP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Huang J; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, USA., Chheda MG; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu., Kim AH; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu., Leuthardt EC; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu., Tran DD; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.
Source: Nature communications [Nat Commun] 2026 Feb 26; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Clinical Trial, Phase I
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
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  Data: <searchLink fieldCode="AU" term="%22Campian+JL%22">Campian JL</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Le+SB%22">Le SB</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ghiaseddin+A%22">Ghiaseddin A</searchLink>; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Butt+OH%22">Butt OH</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Manektalia+H%22">Manektalia H</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+M%22">Rahman M</searchLink>; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Thai+N%22">Thai N</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leidig+WA%22">Leidig WA</searchLink>; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Johanns+T%22">Johanns T</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Ansstas+G%22">Ansstas G</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+AY%22">Zhou AY</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Pugazenthi+S%22">Pugazenthi S</searchLink>; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dunn+GP%22">Dunn GP</searchLink>; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+J%22">Huang J</searchLink>; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Chheda+MG%22">Chheda MG</searchLink>; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Kim+AH%22">Kim AH</searchLink>; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Leuthardt+EC%22">Leuthardt EC</searchLink>; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Tran+DD%22">Tran DD</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.
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