Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial.
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| Title: | Laser interstitial thermal therapy and adjuvant pembrolizumab in recurrent high-grade astrocytoma: a Phase 1/randomized Phase 2b trial. |
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| Authors: | Campian JL; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Le SB; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Ghiaseddin A; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA., Butt OH; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Manektalia H; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Chen D; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Xu Y; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA., Liu J; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, MO, USA., Rahman M; Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USA., Thai N; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA., Leidig WA; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA., Johanns T; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA., Ansstas G; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Zhou AY; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Pugazenthi S; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA., Dunn GP; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Huang J; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA.; Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, USA., Chheda MG; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu.; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. mchheda@wustl.edu., Kim AH; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. alberthkim@wustl.edu., Leuthardt EC; The Brain Tumor Center, Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu.; Taylor Family Department of Neurosurgery, Washington University in St. Louis, St. Louis, MO, USA. leuthardte@wustl.edu., Tran DD; Division of Neuro-Oncology, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; The Brain Tumor Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. david.tran@med.usc.edu. |
| Source: | Nature communications [Nat Commun] 2026 Feb 26; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 26. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial; Clinical Trial, Phase I |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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