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Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice.

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Title: Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice.
Authors: Bem KCP; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil., Talpo TC; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil., da Silva Nogueira GA; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., Zanesco AM; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., Sidarta-Oliveira D; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., da Silva Junior JA; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil., Boschero AC; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil., Velloso LA; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil., de Lima Barbosa HC; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil. bsampaio@unicamp.br.
Source: Molecular neurobiology [Mol Neurobiol] 2026 Feb 27; Vol. 63 (1). Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice.
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  Data: <searchLink fieldCode="AU" term="%22Bem+KCP%22">Bem KCP</searchLink>; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil.<br /><searchLink fieldCode="AU" term="%22Talpo+TC%22">Talpo TC</searchLink>; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Nogueira+GA%22">da Silva Nogueira GA</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Zanesco+AM%22">Zanesco AM</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Sidarta-Oliveira+D%22">Sidarta-Oliveira D</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+Junior+JA%22">da Silva Junior JA</searchLink>; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil.<br /><searchLink fieldCode="AU" term="%22Boschero+AC%22">Boschero AC</searchLink>; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil.<br /><searchLink fieldCode="AU" term="%22Velloso+LA%22">Velloso LA</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Lima+Barbosa+HC%22">de Lima Barbosa HC</searchLink>; Obesity and Comorbidities Research Center, Institute of Biology, State University of Campinas, Campinas, São Paulo, CEP: 13083-864, Brazil. bsampaio@unicamp.br.
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  Data: <searchLink fieldCode="JN" term="%228900963%22">Molecular neurobiology</searchLink> [Mol Neurobiol] 2026 Feb 27; Vol. 63 (1). <i>Date of Electronic Publication: </i>2026 Feb 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Humana+Press%22">Humana Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8900963 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-1182 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208937648%22">08937648 </searchLink><i>NLM ISO Abbreviation: </i>Mol Neurobiol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s12035-026-05729-8
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        Text: English
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      – TitleFull: Central Irisin Administration Attenuates Hypothalamic TLR4/MyD88-Mediated Neuroinflammatory Signaling in Diet-Induced Obese Mice.
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              Text: 2026 Feb 27
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