Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.

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Bibliographic Details
Title: Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
Authors: Reeve MP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. mpreeve@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. mpreeve@broadinstitute.org., Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Karjalainen J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Luo S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kolosov N; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Adams C; Genentech, South San Francisco, CA, USA., Ritari J; Finnish Red Cross Blood Service (Veripalvelu), Helsinki, Finland., Karczewski KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kiiskinen T; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Jiang Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehtonen J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kurki MI; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Khan Z; Genentech, South San Francisco, CA, USA., Partanen J; Finnish Red Cross Blood Service (Veripalvelu), Helsinki, Finland., McCarthy MI; Genentech, South San Francisco, CA, USA., Artomov M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Tuomi T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Helsinki University Hospital, Helsinki, Finland.; Folkhalsan Research Centre, Helsinki, Finland.; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Pirinen M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kero J; Department of Clinical Sciences, Faculty of Medicine, University of Turku, Turku, Finland.; Department of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ripatti S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Corporate Authors: FinnGen
Source: Nature genetics [Nat Genet] 2026 Mar; Vol. 58 (3), pp. 550-559. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1546-1718
DOI:10.1038/s41588-026-02521-1