Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.
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| Title: | Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk. |
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| Authors: | Reeve MP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. mpreeve@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. mpreeve@broadinstitute.org., Kanai M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Karjalainen J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Luo S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kolosov N; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Adams C; Genentech, South San Francisco, CA, USA., Ritari J; Finnish Red Cross Blood Service (Veripalvelu), Helsinki, Finland., Karczewski KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kiiskinen T; Department of Biomedical Data Science, Stanford University, Stanford, CA, USA., Jiang Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehtonen J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kurki MI; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Khan Z; Genentech, South San Francisco, CA, USA., Partanen J; Finnish Red Cross Blood Service (Veripalvelu), Helsinki, Finland., McCarthy MI; Genentech, South San Francisco, CA, USA., Artomov M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Tuomi T; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Helsinki University Hospital, Helsinki, Finland.; Folkhalsan Research Centre, Helsinki, Finland.; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Pirinen M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Kero J; Department of Clinical Sciences, Faculty of Medicine, University of Turku, Turku, Finland.; Department of Pediatrics and Adolescent Medicine, Turku University Hospital, Turku, Finland., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA, USA., Daly MJ; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Ripatti S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Faculty of Medicine, University of Helsinki, Helsinki, Finland. |
| Corporate Authors: | FinnGen |
| Source: | Nature genetics [Nat Genet] 2026 Mar; Vol. 58 (3), pp. 550-559. Date of Electronic Publication: 2026 Feb 26. |
| Publication Type: | Journal Article; Meta-Analysis |
| Journal Info: | Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41748903 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41748903 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41588-026-02521-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 550 Titles: – TitleFull: Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Reeve MP – PersonEntity: Name: NameFull: Kanai M – PersonEntity: Name: NameFull: Graham DB – PersonEntity: Name: NameFull: Karjalainen J – PersonEntity: Name: NameFull: Luo S – PersonEntity: Name: NameFull: Kolosov N – PersonEntity: Name: NameFull: Adams C – PersonEntity: Name: NameFull: Ritari J – PersonEntity: Name: NameFull: Karczewski KJ – PersonEntity: Name: NameFull: Kiiskinen T – PersonEntity: Name: NameFull: Jiang Y – PersonEntity: Name: NameFull: Fuller Z – PersonEntity: Name: NameFull: Mehtonen J – PersonEntity: Name: NameFull: Kurki MI – PersonEntity: Name: NameFull: Khan Z – PersonEntity: Name: NameFull: Partanen J – PersonEntity: Name: NameFull: McCarthy MI – PersonEntity: Name: NameFull: Artomov M – PersonEntity: Name: NameFull: Palotie A – PersonEntity: Name: NameFull: Tuomi T – PersonEntity: Name: NameFull: Pirinen M – PersonEntity: Name: NameFull: Kero J – PersonEntity: Name: NameFull: Xavier RJ – PersonEntity: Name: NameFull: Daly MJ – PersonEntity: Name: NameFull: Ripatti S IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1546-1718 Numbering: – Type: volume Value: 58 – Type: issue Value: 3 Titles: – TitleFull: Nature genetics Type: main |
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