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Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury.

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Title: Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury.
Authors: Shie MY; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan. eric@mail.cmu.edu.tw.; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan. eric@mail.cmu.edu.tw.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 413305, Taiwan. eric@mail.cmu.edu.tw., Chiu CD; School of Medicine, China Medical University, Taichung, 406040, Taiwan.; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan., Chen Y; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, 402202, Taiwan., Lin YH; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan., Yu MH; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan.; Institute of Translational Medicine and New Drug Development, Medical University, Taichung, 406040, Taiwan., Chiu YP; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan., Chiu PF; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan., Chen CY; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404327, Taiwan., Chen YW; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404327, Taiwan., Chen MC; Translational Cell Therapy Center, China Medical University Hospital, Taichung, 404327, Taiwan., Cho DY; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan. dycho1212@gmail.com.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan. dycho1212@gmail.com.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan. dycho1212@gmail.com.
Source: Journal of nanobiotechnology [J Nanobiotechnology] 2026 Feb 26; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA for motor recovery in spinal cord injury.
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  Data: <searchLink fieldCode="AU" term="%22Shie+MY%22">Shie MY</searchLink>; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan. eric@mail.cmu.edu.tw.; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan. eric@mail.cmu.edu.tw.; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 413305, Taiwan. eric@mail.cmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chiu+CD%22">Chiu CD</searchLink>; School of Medicine, China Medical University, Taichung, 406040, Taiwan.; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Neuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, 402202, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YH%22">Lin YH</searchLink>; Department of Biomedical Engineering, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yu+MH%22">Yu MH</searchLink>; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan.; Institute of Translational Medicine and New Drug Development, Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+YP%22">Chiu YP</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+PF%22">Chiu PF</searchLink>; Spine Center, China Medical University Hospital, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YW%22">Chen YW</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan.; Research & Development Center for x-Dimensional Extracellular Vesicles, China Medical University Hospital, Taichung, 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+MC%22">Chen MC</searchLink>; Translational Cell Therapy Center, China Medical University Hospital, Taichung, 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cho+DY%22">Cho DY</searchLink>; Xenotransplantation Translational Research Center, China Medical University Hospital, Taichung, 404327, Taiwan. dycho1212@gmail.com.; Department of Neurosurgery, China Medical University Hospital, Taichung, 404327, Taiwan. dycho1212@gmail.com.; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 406040, Taiwan. dycho1212@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101152208%22">Journal of nanobiotechnology</searchLink> [J Nanobiotechnology] 2026 Feb 26; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101152208 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-3155 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214773155%22">14773155 </searchLink><i>NLM ISO Abbreviation: </i>J Nanobiotechnology <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12951-026-04222-7
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        Text: English
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            – D: 26
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              Text: 2026 Feb 26
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              Y: 2026
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