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Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.

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Title: Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.
Authors: Guidetti C; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Papakostas GI; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Stahl S; Department of Psychiatry, VAMC (SD), University of California, San Diego.; Neuroscience Education Institute, Carlsbad, California., Pani L; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, Florida.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena., De Martin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Mattarei A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Comai S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Kröger C; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Champasa P; Daje Life Sciences, LLC, Somerville, Massachusetts., Gorodetzky CW; Consultant in Pharmaceutical Medicine, Kansas City, Missouri., Vocci FJ; Friends Research Institute, Baltimore, Maryland., Kosten TR; Baylor College of Medicine, Houston, Texas., Bushnell D; Cytel Inc., Waltham, Massachusetts, USA., Kappler M; Cytel Inc., Waltham, Massachusetts, USA., Folli F; Department of Health Sciences, University of Milan, Milan, Italy., Inturrisi CE; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Pappagallo M; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Manfredi PL; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Fava M; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Source: International clinical psychopharmacology [Int Clin Psychopharmacol] 2026 Jul 01; Vol. 41 (4), pp. 213-224. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial
Journal Info: Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 8609061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5857 (Electronic) Linking ISSN: 02681315 NLM ISO Abbreviation: Int Clin Psychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.
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  Data: <searchLink fieldCode="AU" term="%22Guidetti+C%22">Guidetti C</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Papakostas+GI%22">Papakostas GI</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Stahl+S%22">Stahl S</searchLink>; Department of Psychiatry, VAMC (SD), University of California, San Diego.; Neuroscience Education Institute, Carlsbad, California.<br /><searchLink fieldCode="AU" term="%22Pani+L%22">Pani L</searchLink>; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, Florida.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena.<br /><searchLink fieldCode="AU" term="%22De+Martin+S%22">De Martin S</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Mattarei+A%22">Mattarei A</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Comai+S%22">Comai S</searchLink>; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Kröger+C%22">Kröger C</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Champasa+P%22">Champasa P</searchLink>; Daje Life Sciences, LLC, Somerville, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gorodetzky+CW%22">Gorodetzky CW</searchLink>; Consultant in Pharmaceutical Medicine, Kansas City, Missouri.<br /><searchLink fieldCode="AU" term="%22Vocci+FJ%22">Vocci FJ</searchLink>; Friends Research Institute, Baltimore, Maryland.<br /><searchLink fieldCode="AU" term="%22Kosten+TR%22">Kosten TR</searchLink>; Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Bushnell+D%22">Bushnell D</searchLink>; Cytel Inc., Waltham, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kappler+M%22">Kappler M</searchLink>; Cytel Inc., Waltham, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Folli+F%22">Folli F</searchLink>; Department of Health Sciences, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Inturrisi+CE%22">Inturrisi CE</searchLink>; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Pappagallo+M%22">Pappagallo M</searchLink>; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Manfredi+PL%22">Manfredi PL</searchLink>; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Fava+M%22">Fava M</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
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  Data: <searchLink fieldCode="JN" term="%228609061%22">International clinical psychopharmacology</searchLink> [Int Clin Psychopharmacol] 2026 Jul 01; Vol. 41 (4), pp. 213-224. <i>Date of Electronic Publication: </i>2026 Feb 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+And+Wilkins%22">Lippincott Williams And Wilkins </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8609061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1473-5857 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202681315%22">02681315 </searchLink><i>NLM ISO Abbreviation: </i>Int Clin Psychopharmacol <i>Subsets: </i>MEDLINE
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