Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.
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| Title: | Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants. |
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| Authors: | Guidetti C; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Papakostas GI; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Stahl S; Department of Psychiatry, VAMC (SD), University of California, San Diego.; Neuroscience Education Institute, Carlsbad, California., Pani L; Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Miami, Miami, Florida.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena., De Martin S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Mattarei A; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy., Comai S; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Kröger C; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Champasa P; Daje Life Sciences, LLC, Somerville, Massachusetts., Gorodetzky CW; Consultant in Pharmaceutical Medicine, Kansas City, Missouri., Vocci FJ; Friends Research Institute, Baltimore, Maryland., Kosten TR; Baylor College of Medicine, Houston, Texas., Bushnell D; Cytel Inc., Waltham, Massachusetts, USA., Kappler M; Cytel Inc., Waltham, Massachusetts, USA., Folli F; Department of Health Sciences, University of Milan, Milan, Italy., Inturrisi CE; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Pappagallo M; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Manfredi PL; MGGM LLC, Kerhonkson, New York.; Levomecor Inc., Miami Beach, Florida, USA., Fava M; Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts. |
| Source: | International clinical psychopharmacology [Int Clin Psychopharmacol] 2026 Jul 01; Vol. 41 (4), pp. 213-224. Date of Electronic Publication: 2026 Feb 17. |
| Publication Type: | Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial |
| Journal Info: | Publisher: Lippincott Williams And Wilkins Country of Publication: England NLM ID: 8609061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5857 (Electronic) Linking ISSN: 02681315 NLM ISO Abbreviation: Int Clin Psychopharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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