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Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.

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Title: Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.
Authors: Perera-Cruz O; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain., Solé-Padullés C; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain., Mulet-Pons L; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain., Cabello-Toscano M; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain., Morse RM; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain., Abellaneda-Pérez K; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès 08193, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain., Perellón-Alfonso R; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.; Unit for Cognitive Neuroscience, Institute of Neurosciences, University of Barcelona, Barcelona 08035, Spain.; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain., Cattaneo G; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain., Solana-Sánchez J; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain., Alviarez-Schulze V; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain., Bargalló N; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain.; Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona 08036, Spain., Fortea J; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Barcelona 08025, Spain.; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona 08029, Spain., Tormos JM; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, València 46001, Spain., Pascual-Leone A; Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney WolkCenter for Memory Health, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg 41390, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London LN WC1N3BG, UK.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 43180, Sweden.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.; UK Dementia Research Institute at UCL, London W1B 3HH, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Tseung Kwan O, Hong Kong, China.; Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka 560012, India., Vaqué-Alcázar L; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Barcelona 08025, Spain., Bartrés-Faz D; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.
Source: Brain communications [Brain Commun] 2026 Jan 10; Vol. 8 (1), pp. fcaf511. Date of Electronic Publication: 2026 Jan 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.
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  Data: <searchLink fieldCode="AU" term="%22Perera-Cruz+O%22">Perera-Cruz O</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Solé-Padullés+C%22">Solé-Padullés C</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Mulet-Pons+L%22">Mulet-Pons L</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Cabello-Toscano+M%22">Cabello-Toscano M</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Morse+RM%22">Morse RM</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Abellaneda-Pérez+K%22">Abellaneda-Pérez K</searchLink>; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès 08193, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.<br /><searchLink fieldCode="AU" term="%22Perellón-Alfonso+R%22">Perellón-Alfonso R</searchLink>; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.; Unit for Cognitive Neuroscience, Institute of Neurosciences, University of Barcelona, Barcelona 08035, Spain.; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain.<br /><searchLink fieldCode="AU" term="%22Cattaneo+G%22">Cattaneo G</searchLink>; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.<br /><searchLink fieldCode="AU" term="%22Solana-Sánchez+J%22">Solana-Sánchez J</searchLink>; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.<br /><searchLink fieldCode="AU" term="%22Alviarez-Schulze+V%22">Alviarez-Schulze V</searchLink>; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona 08916, Spain.<br /><searchLink fieldCode="AU" term="%22Bargalló+N%22">Bargalló N</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Centre for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain.; Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital Clinic of Barcelona, University of Barcelona, Barcelona 08036, Spain.<br /><searchLink fieldCode="AU" term="%22Fortea+J%22">Fortea J</searchLink>; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Barcelona 08025, Spain.; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona 08029, Spain.<br /><searchLink fieldCode="AU" term="%22Tormos+JM%22">Tormos JM</searchLink>; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.; Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, València 46001, Spain.<br /><searchLink fieldCode="AU" term="%22Pascual-Leone+A%22">Pascual-Leone A</searchLink>; Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney WolkCenter for Memory Health, Hebrew SeniorLife, Harvard Medical School, Boston, MA 02131, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg 41390, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London LN WC1N3BG, UK.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 43180, Sweden.; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.; UK Dementia Research Institute at UCL, London W1B 3HH, UK.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Tseung Kwan O, Hong Kong, China.; Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka 560012, India.<br /><searchLink fieldCode="AU" term="%22Vaqué-Alcázar+L%22">Vaqué-Alcázar L</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Barcelona 08025, Spain.<br /><searchLink fieldCode="AU" term="%22Bartrés-Faz+D%22">Bartrés-Faz D</searchLink>; Department of Medicine, Faculty of Medicine and Health Sciences and Institute of Neurosciences, University of Barcelona, Barcelona 08036, Spain.; August Pi I Sunyer Institute of Biomedical Research (IDIBAPS), Barcelona 08036, Spain.; Guttmann Institute, Institut Universitari de Neurorehabilitació adscrit a la Universitat Autònoma de Barcelona, Badalona 08916, Spain.
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