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Self-amplifying RNA-based CAR T cell therapy with enhanced duration and multi-genic logic functions.

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Title: Self-amplifying RNA-based CAR T cell therapy with enhanced duration and multi-genic logic functions.
Authors: Gu Y; Division of Materials Science & Engineering, Boston University, Boston, MA, USA., Choi J; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Mutha D; Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Wu C; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA., Ganem NJ; Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Grinstaff MW; Division of Materials Science & Engineering, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Department of Chemistry, Boston University, Boston, MA, USA., Wong WW; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Mar 21. Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41756931
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: <searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Division of Materials Science & Engineering, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Choi+J%22">Choi J</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mutha+D%22">Mutha D</searchLink>; Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ganem+NJ%22">Ganem NJ</searchLink>; Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Grinstaff+MW%22">Grinstaff MW</searchLink>; Division of Materials Science & Engineering, Boston University, Boston, MA, USA.; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Department of Chemistry, Boston University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+WW%22">Wong WW</searchLink>; Department of Biomedical Engineering, Boston University, Boston, MA, USA.; Biological Design Center, Boston University, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Mar 21. <i>Date of Electronic Publication: </i>2026 Mar 21.
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        Value: 10.64898/2026.02.18.706661
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              Text: 2026 Mar 21
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