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Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.

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Title: Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.
Authors: Senkevich K; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Specialized Medicine, Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada., Parlar SC; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Chantereault C; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Liu L; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Yu E; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada., Rudakou U; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada., Ahmad J; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada., Ruskey JA; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada., Asayesh F; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada., Spiegelman D; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada., Waters C; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA., Monchi O; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, Alberta, Canada., Dauvilliers Y; National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Montpellier, France., Dupré N; Neuroscience Research Program, CHU de Québec-Université Laval Research Center, Quebec City, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada., Greenbaum L; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel., Hassin-Baer S; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; The Movement Disorders Institute, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel., Miliukhina I; Institute of the Human Brain of RAS, St. Petersburg, Russia.; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia., Timofeeva A; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia., Emelyanov A; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia., Pchelina S; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia., Alcalay RN; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; The Movement Disorders Institute, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel., Gan-Or Z; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 18. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 41757160
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Senkevich+K%22">Senkevich K</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Specialized Medicine, Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Parlar+SC%22">Parlar SC</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chantereault+C%22">Chantereault C</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Yu+E%22">Yu E</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rudakou+U%22">Rudakou U</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmad+J%22">Ahmad J</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Ruskey+JA%22">Ruskey JA</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Asayesh+F%22">Asayesh F</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Spiegelman+D%22">Spiegelman D</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Waters+C%22">Waters C</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA.<br /><searchLink fieldCode="AU" term="%22Monchi+O%22">Monchi O</searchLink>; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, Alberta, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Dauvilliers+Y%22">Dauvilliers Y</searchLink>; National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Dupré+N%22">Dupré N</searchLink>; Neuroscience Research Program, CHU de Québec-Université Laval Research Center, Quebec City, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Greenbaum+L%22">Greenbaum L</searchLink>; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Hassin-Baer+S%22">Hassin-Baer S</searchLink>; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; The Movement Disorders Institute, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Miliukhina+I%22">Miliukhina I</searchLink>; Institute of the Human Brain of RAS, St. Petersburg, Russia.; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Timofeeva+A%22">Timofeeva A</searchLink>; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Emelyanov+A%22">Emelyanov A</searchLink>; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Pchelina+S%22">Pchelina S</searchLink>; First Pavlov State Medical University of St. Petersburg, Saint-Petersburg, Russia.<br /><searchLink fieldCode="AU" term="%22Alcalay+RN%22">Alcalay RN</searchLink>; Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, NY, USA.; Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.; The Movement Disorders Institute, Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.<br /><searchLink fieldCode="AU" term="%22Gan-Or+Z%22">Gan-Or Z</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.; Department of Human Genetics, McGill University, Montréal, QC, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Feb 18. <i>Date of Electronic Publication: </i>2026 Feb 18.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.02.18.26346391
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        Text: English
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