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Contribution of dominant and recessive model effects to the genetic architecture of Idiopathic Pulmonary Fibrosis.

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Title: Contribution of dominant and recessive model effects to the genetic architecture of Idiopathic Pulmonary Fibrosis.
Authors: Hernandez-Beeftink T; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Donoghue LJ; Genentech, California, USA., Izquierdo A; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Moss ST; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Chin D; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Guillen-Guio B; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Bhatti KF; Imperial College London, London, UK., Biddie S; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Shrine N; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Packer R; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.; Leicester British Heart Foundation Centre of Research Excellence, Leicester, UK., Adegunsoye A; University of Chicago, Chicago, USA., Booth HL; University College London Hospitals, London, UK., Fahy WA; GlaxoSmithKline, London, UK., Fingerlin TE; National Jewish Health, Colorado, USA., Hall IP; Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Hart SP; University of Hull, Hull, UK., Hill MR; University of Oxford, Oxford, UK., Hirani N; University of Edinburgh, Edinburgh, UK., Kaminski N; Yale School of Medicine, Connecticut, USA., Lopez-Jimenez E; Imperial College London, London, UK., Lorenzo-Salazar JM; Genomics Division, Instituto Tecnologico y de Energias Renovables, Santa Cruz de Tenerife, Spain., Ma SF; University of Virginia, Virginia, USA., McAnulty RJ; University College London, London, UK., McCarthy MI; Genentech, California, USA., Stockwell AD; Genentech, California, USA., Maher TM; NIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK., Millar AB; University of Bristol, Bristol, UK., Molyneaux PL; National Institute for Health Research Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK., Molina-Molina M; Servei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain.; Campus de Bellvitge, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Navaratnam V; Department of Respiratory Medicine, Sir Charles Gardiner Hospital, Perth, Australia.; Centre for Respiratory Research, University of Western Australia, Perth, Australia., Neighbors M; Genentech, California, USA., Oldham JM; University of Michigan, Michigan, USA., Parfrey H; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Saini G; University of Nottingham, Nottingham, UK., Sayers I; Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Sheng XR; Genentech, California, USA., Strek ME; University of Chicago, Chicago, USA., Stewart I; NIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK., Tobin MD; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Whyte MK; University of Edinburgh, Edinburgh, UK., Zhang Y; University of Pittsburgh, Pittsburgh, USA., Martinez FJ; UMass Chan Medical School, Massachusetts, USA., Yaspan BL; Genentech, California, USA., Reynolds CJ; Imperial College, London, UK., Schwartz DA; University of Colorado Medicine, Colorado, USA., Flores C; Genomics Division, Instituto Tecnologico y de Energias Renovables, Santa Cruz de Tenerife, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Instituto de Investigación Sanitaria de Canarias, Santa Cruz de Tenerife, Spain.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain., Noth I; University of Virginia, Virginia, USA., John AE; Imperial College London, London, UK., Jenkins RG; NIHR Imperial Biomedical Research Unit, National Heart and Lung Institute, Imperial College London, London, UK., Allen RJ; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Leavy OC; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Wain LV; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.
Corporate Authors: CleanUP-IPF Investigators of the Pulmonary Trials Cooperative
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 19. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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