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Deep Learning and Fluid Dynamics On-Site CT-FFR Solution Compared to Off-Site FFRct and Invasive FFR.

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Title: Deep Learning and Fluid Dynamics On-Site CT-FFR Solution Compared to Off-Site FFRct and Invasive FFR.
Authors: Fazzari F; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Khenkina N; Postgraduation School in Radiodiagnostics, University of Milan, Milan, Italy., Piccinni G; Radiology Unit, Department of Medical Surgical Sciences and Translational Medicine, 'Sapienza' University of Rome, Sant'Andrea University Hospital, Rome, Italy., Biroli M; School of Medicine, University of Milan, Milan, Italy., Annoni A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Berna G; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Cannata F; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Carerj ML; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Celeste F; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Del Torto A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Formenti A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Frappampina A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Fusini L; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Gripari P; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Ghulam Alì S; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Junod D; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Maltagliati A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Mancini ME; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Mantegazza V; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Maragna R; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Marchetti F; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Sbordone FP; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Stankowski K; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Tassetti L; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Volpe A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., La Grutta L; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-ProMISE, University of Palermo, Palermo, Italy., Carafiello G; Postgraduation School in Radiodiagnostics, University of Milan, Milan, Italy., Laghi A; Radiology Unit, Department of Medical Surgical Sciences and Translational Medicine, 'Sapienza' University of Rome, Sant'Andrea University Hospital, Rome, Italy., Guaricci AI; University Cardiologic Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari Aldo Moro, Bari, Italy., De Marco F; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy., Galli S; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy., Trabattoni D; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy., Montorsi P; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy., Pedrinelli R; Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy., Sinagra G; Cardiology Specialty School, University of Trieste, Trieste, Italy; Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Trieste, Italy., Filardi PP; Department of Advanced Biomedical Sciences, University Federico II of Naples, Naples, Italy., Baggiano A; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Muratori M; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Pergola V; 35 Cardiology Clinic, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy., Mushtaq S; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy., Pontone G; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Electronic address: gianluca.pontone@ccfm.it.
Corporate Authors: Italian Society of Cardiology (SIC) Working Group on Cardiac CT and Nuclear Cardiology
Source: JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2026 Apr; Vol. 19 (4), pp. 494-512. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101467978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7591 (Electronic) Linking ISSN: 18767591 NLM ISO Abbreviation: JACC Cardiovasc Imaging Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Deep Learning and Fluid Dynamics On-Site CT-FFR Solution Compared to Off-Site FFRct and Invasive FFR.
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  Data: <searchLink fieldCode="AU" term="%22Fazzari+F%22">Fazzari F</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Khenkina+N%22">Khenkina N</searchLink>; Postgraduation School in Radiodiagnostics, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Piccinni+G%22">Piccinni G</searchLink>; Radiology Unit, Department of Medical Surgical Sciences and Translational Medicine, 'Sapienza' University of Rome, Sant'Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Biroli+M%22">Biroli M</searchLink>; School of Medicine, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Annoni+A%22">Annoni A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Berna+G%22">Berna G</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cannata+F%22">Cannata F</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Carerj+ML%22">Carerj ML</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Celeste+F%22">Celeste F</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Torto+A%22">Del Torto A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Formenti+A%22">Formenti A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Frappampina+A%22">Frappampina A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fusini+L%22">Fusini L</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Gripari+P%22">Gripari P</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ghulam+Alì+S%22">Ghulam Alì S</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Junod+D%22">Junod D</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Maltagliati+A%22">Maltagliati A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mancini+ME%22">Mancini ME</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mantegazza+V%22">Mantegazza V</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Maragna+R%22">Maragna R</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marchetti+F%22">Marchetti F</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sbordone+FP%22">Sbordone FP</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stankowski+K%22">Stankowski K</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tassetti+L%22">Tassetti L</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Volpe+A%22">Volpe A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22La+Grutta+L%22">La Grutta L</searchLink>; Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-ProMISE, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Carafiello+G%22">Carafiello G</searchLink>; Postgraduation School in Radiodiagnostics, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Laghi+A%22">Laghi A</searchLink>; Radiology Unit, Department of Medical Surgical Sciences and Translational Medicine, 'Sapienza' University of Rome, Sant'Andrea University Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Guaricci+AI%22">Guaricci AI</searchLink>; University Cardiologic Unit, Interdisciplinary Department of Medicine, Polyclinic University Hospital, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22De+Marco+F%22">De Marco F</searchLink>; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Galli+S%22">Galli S</searchLink>; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Trabattoni+D%22">Trabattoni D</searchLink>; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Montorsi+P%22">Montorsi P</searchLink>; Department of Interventional Cardiology, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pedrinelli+R%22">Pedrinelli R</searchLink>; Cardiac, Thoracic and Vascular Department, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Sinagra+G%22">Sinagra G</searchLink>; Cardiology Specialty School, University of Trieste, Trieste, Italy; Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Filardi+PP%22">Filardi PP</searchLink>; Department of Advanced Biomedical Sciences, University Federico II of Naples, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Baggiano+A%22">Baggiano A</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Muratori+M%22">Muratori M</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pergola+V%22">Pergola V</searchLink>; 35 Cardiology Clinic, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Mushtaq+S%22">Mushtaq S</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pontone+G%22">Pontone G</searchLink>; Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. 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