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Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13.

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Title: Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13.
Authors: Tang S; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, China., Zhang J; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China., He Z; Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China., Liu G; Department of Emergency, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China., Nie S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Shi X; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China., Zhang K; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China., Pi D; Department of Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing 400014, China., Gui X; Department of Emergency, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China., He Y; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Zhao S; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China., Liu Z; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China., Mao L; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China., Jiang Y; Department of Respiratory Medicine, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China., Wu M; Innovation Centre of Chongqing Medical University, Chongqing 400016, China., Cao J; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China., Qiu J; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, China., Chen C; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, China., Zou Z; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.; Western Institute of Digital-Intelligent Medicine, Chongqing 401329, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 03; Vol. 123 (9), pp. e2519332123. Date of Electronic Publication: 2026 Feb 27.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13.
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  Data: <searchLink fieldCode="AU" term="%22Tang+S%22">Tang S</searchLink>; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22He+Z%22">He Z</searchLink>; Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+G%22">Liu G</searchLink>; Department of Emergency, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China.<br /><searchLink fieldCode="AU" term="%22Nie+S%22">Nie S</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Pi+D%22">Pi D</searchLink>; Department of Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.<br /><searchLink fieldCode="AU" term="%22Gui+X%22">Gui X</searchLink>; Department of Emergency, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Zhao+S%22">Zhao S</searchLink>; Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention (Ministry of Education), Department of Urology of the Second Affiliated Hospital, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Mao+L%22">Mao L</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Department of Respiratory Medicine, The University-Town Hospital of Chongqing Medical University, Chongqing 401331, China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Innovation Centre of Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Qiu+J%22">Qiu J</searchLink>; Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Occupational and Environmental Health, School of Public Health, Chongqing Medical University, Chongqing 400016, China.<br /><searchLink fieldCode="AU" term="%22Zou+Z%22">Zou Z</searchLink>; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.; Western Institute of Digital-Intelligent Medicine, Chongqing 401329, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 03; Vol. 123 (9), pp. e2519332123. <i>Date of Electronic Publication: </i>2026 Feb 27.
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