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A Comparative Analysis of Fatal Outcomes in 5,370 Geriatric Versus 12,254 Nongeriatric Adult Patients: A Clozapine Study in VigiBase.

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Title: A Comparative Analysis of Fatal Outcomes in 5,370 Geriatric Versus 12,254 Nongeriatric Adult Patients: A Clozapine Study in VigiBase.
Authors: de Leon J; Mental Health Research Center (JdL), Eastern State Hospital, Lexington, KY; Biomedical Research Centre in Mental Health Net (CIBERSAM) (JdL), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address: jdeleon@uky.edu., Ruan CJ; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders (CJR), Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection (CJR), Capital Medical University, Beijing, China., Schoretsanitis G; The Department of Psychiatry (GS), Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; The Zucker Hillside Hospital (GS), Psychiatry Research, Northwell Health, Glen Oaks, NY; Zucker School of Medicine at Hofstra/Northwell (GS), Hempstead, NY., Verdoux H; University of Bordeaux (HV), Inserm, Bordeaux Population Health Research Center, team pharmacoepidemiology, Bordeaux, France., Friedman J; Movement Disorders Program (JF), Butler Hospital Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI., Sanz EJ; The Department of Physical Medicine and Pharmacology (EJS), School of Medicine, Universidad de La Laguna, Canary Islands, Spain; Hospital Universitario de Canarias (EJS), Tenerife, Spain., De Las Cuevas C; Department of Internal Medicine (CDlC), Dermatology and Psychiatry, School of Medicine, and Instituto Universitario de Neurociencia (IUNE), University of La Laguna, Canary Islands, Spain.
Source: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2026 Apr; Vol. 34 (4), pp. 591-601. Date of Electronic Publication: 2026 Feb 20.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22de+Leon+J%22">de Leon J</searchLink>; Mental Health Research Center (JdL), Eastern State Hospital, Lexington, KY; Biomedical Research Centre in Mental Health Net (CIBERSAM) (JdL), Santiago Apostol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address: jdeleon@uky.edu.<br /><searchLink fieldCode="AU" term="%22Ruan+CJ%22">Ruan CJ</searchLink>; The National Clinical Research Centre for Mental Disorders & Beijing Key Lab of Mental Disorders (CJR), Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection (CJR), Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Schoretsanitis+G%22">Schoretsanitis G</searchLink>; The Department of Psychiatry (GS), Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland; The Zucker Hillside Hospital (GS), Psychiatry Research, Northwell Health, Glen Oaks, NY; Zucker School of Medicine at Hofstra/Northwell (GS), Hempstead, NY.<br /><searchLink fieldCode="AU" term="%22Verdoux+H%22">Verdoux H</searchLink>; University of Bordeaux (HV), Inserm, Bordeaux Population Health Research Center, team pharmacoepidemiology, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Friedman+J%22">Friedman J</searchLink>; Movement Disorders Program (JF), Butler Hospital Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI.<br /><searchLink fieldCode="AU" term="%22Sanz+EJ%22">Sanz EJ</searchLink>; The Department of Physical Medicine and Pharmacology (EJS), School of Medicine, Universidad de La Laguna, Canary Islands, Spain; Hospital Universitario de Canarias (EJS), Tenerife, Spain.<br /><searchLink fieldCode="AU" term="%22De+Las+Cuevas+C%22">De Las Cuevas C</searchLink>; Department of Internal Medicine (CDlC), Dermatology and Psychiatry, School of Medicine, and Instituto Universitario de Neurociencia (IUNE), University of La Laguna, Canary Islands, Spain.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9309609 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-7214 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210647481%22">10647481 </searchLink><i>NLM ISO Abbreviation: </i>Am J Geriatr Psychiatry <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jagp.2025.08.010
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              Text: 2026 Apr
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