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A first-in-human phase 1 study of the SHP2 inhibitor BBP-398 in patients with advanced solid tumors.

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Title: A first-in-human phase 1 study of the SHP2 inhibitor BBP-398 in patients with advanced solid tumors.
Authors: Falchook G; Sarah Cannon Research Institute at HealthONE, Denver, CO, USA., Braganca Xavier C; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Van Veenhuyzen D; BridgeBio, Palo Alto, CA, USA., Malhotra J; City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Sadeghi S; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Kalebasty AR; University of California, Irvine, Irvine, CA, USA., Wood L; BridgeBio, Palo Alto, CA, USA., Rahman F; BridgeBio, Palo Alto, CA, USA., Li E; PharmaStat, Fremont, CA, USA., Pak Y; BridgeBio, Palo Alto, CA, USA., Khalil M; The University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center, Birmingham, AL, USA., Spira AI; NEXT Oncology, Fairfax, VA, USA., Sommerhalder D; NEXT Oncology, San Antonio, TX, USA., Garrido-Laguna I; University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA., Hong DS; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. dshong@mdanderson.org.
Source: NPJ precision oncology [NPJ Precis Oncol] 2026 Feb 28; Vol. 10 (1). Date of Electronic Publication: 2026 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A first-in-human phase 1 study of the SHP2 inhibitor BBP-398 in patients with advanced solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Falchook+G%22">Falchook G</searchLink>; Sarah Cannon Research Institute at HealthONE, Denver, CO, USA.<br /><searchLink fieldCode="AU" term="%22Braganca+Xavier+C%22">Braganca Xavier C</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Van+Veenhuyzen+D%22">Van Veenhuyzen D</searchLink>; BridgeBio, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+J%22">Malhotra J</searchLink>; City of Hope Comprehensive Cancer Center, Duarte, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sadeghi+S%22">Sadeghi S</searchLink>; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kalebasty+AR%22">Kalebasty AR</searchLink>; University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wood+L%22">Wood L</searchLink>; BridgeBio, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+F%22">Rahman F</searchLink>; BridgeBio, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+E%22">Li E</searchLink>; PharmaStat, Fremont, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pak+Y%22">Pak Y</searchLink>; BridgeBio, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Khalil+M%22">Khalil M</searchLink>; The University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Spira+AI%22">Spira AI</searchLink>; NEXT Oncology, Fairfax, VA, USA.<br /><searchLink fieldCode="AU" term="%22Sommerhalder+D%22">Sommerhalder D</searchLink>; NEXT Oncology, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Garrido-Laguna+I%22">Garrido-Laguna I</searchLink>; University of Utah Huntsman Cancer Institute, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Hong+DS%22">Hong DS</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. dshong@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 Feb 28; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 Feb 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE
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