SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.
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| Title: | SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study. |
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| Authors: | Chia PHJ; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada., Toyonaga T; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520., Tong J; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Le H; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada., Dias M; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520., Boyle AJ; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada., Raymond R; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada., Longbrake EE; Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06520., Huang Y; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520., Carson RE; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520., Airas L; Neurocenter, Turku University Hospital, University of Turku, Turku 20521, Finland., Vasdev N; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada., Chen MK; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520., Zheng C; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2517709123. Date of Electronic Publication: 2026 Mar 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41774796 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chia+PHJ%22">Chia PHJ</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.<br /><searchLink fieldCode="AU" term="%22Toyonaga+T%22">Toyonaga T</searchLink>; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Tong+J%22">Tong J</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.<br /><searchLink fieldCode="AU" term="%22Le+H%22">Le H</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.<br /><searchLink fieldCode="AU" term="%22Dias+M%22">Dias M</searchLink>; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Boyle+AJ%22">Boyle AJ</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.<br /><searchLink fieldCode="AU" term="%22Raymond+R%22">Raymond R</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.<br /><searchLink fieldCode="AU" term="%22Longbrake+EE%22">Longbrake EE</searchLink>; Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Carson+RE%22">Carson RE</searchLink>; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Airas+L%22">Airas L</searchLink>; Neurocenter, Turku University Hospital, University of Turku, Turku 20521, Finland.<br /><searchLink fieldCode="AU" term="%22Vasdev+N%22">Vasdev N</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+MK%22">Chen MK</searchLink>; Department of Radiology and Biomedical Imaging, Yale School of Medicine, Yale University, New Haven, CT 06520.<br /><searchLink fieldCode="AU" term="%22Zheng+C%22">Zheng C</searchLink>; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.; Department of Pharmacology and Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5G 2C8, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada.; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2517709123. <i>Date of Electronic Publication: </i>2026 Mar 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41774796 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2517709123 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2517709123 Titles: – TitleFull: SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chia PHJ – PersonEntity: Name: NameFull: Toyonaga T – PersonEntity: Name: NameFull: Tong J – PersonEntity: Name: NameFull: Le H – PersonEntity: Name: NameFull: Dias M – PersonEntity: Name: NameFull: Boyle AJ – PersonEntity: Name: NameFull: Raymond R – PersonEntity: Name: NameFull: Longbrake EE – PersonEntity: Name: NameFull: Huang Y – PersonEntity: Name: NameFull: Carson RE – PersonEntity: Name: NameFull: Airas L – PersonEntity: Name: NameFull: Vasdev N – PersonEntity: Name: NameFull: Chen MK – PersonEntity: Name: NameFull: Zheng C IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 03 Text: 2026 Mar 10 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 123 – Type: issue Value: 10 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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