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Longitudinal deep multi-omics profiling in a CLN3Δex7/8 minipig model identifies biomarker signatures of disease.

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Title: Longitudinal deep multi-omics profiling in a CLN3Δex7/8 minipig model identifies biomarker signatures of disease.
Authors: Rechtzigel MJ; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA., Lee B; Seer, Inc., Redwood City, CA, USA., Neville C; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA., Huang T; Seer, Inc., Redwood City, CA, USA., Díaz R; Sanford Burnham Prebys, La Jolla, CA, USA., Campos AR; Sanford Burnham Prebys, La Jolla, CA, USA., Motamedchaboki K; Seer, Inc., Redwood City, CA, USA., Hornburg D; Seer, Inc., Redwood City, CA, USA., Johnson TB; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA., Swier VJ; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA., Weimer JM; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA.; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, USA., Brudvig JJ; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA. jbrudvig@amicusrx.com.; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA. jbrudvig@amicusrx.com.; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, USA. jbrudvig@amicusrx.com.
Source: Communications medicine [Commun Med (Lond)] 2026 Mar 03; Vol. 6 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Portfolio Country of Publication: England NLM ID: 9918250414506676 Publication Model: Electronic Cited Medium: Internet ISSN: 2730-664X (Electronic) Linking ISSN: 2730664X NLM ISO Abbreviation: Commun Med (Lond) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Longitudinal deep multi-omics profiling in a CLN3<superscript>Δex7/8</superscript> minipig model identifies biomarker signatures of disease.
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  Data: <searchLink fieldCode="AU" term="%22Rechtzigel+MJ%22">Rechtzigel MJ</searchLink>; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.<br /><searchLink fieldCode="AU" term="%22Lee+B%22">Lee B</searchLink>; Seer, Inc., Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Neville+C%22">Neville C</searchLink>; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+T%22">Huang T</searchLink>; Seer, Inc., Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Díaz+R%22">Díaz R</searchLink>; Sanford Burnham Prebys, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Campos+AR%22">Campos AR</searchLink>; Sanford Burnham Prebys, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Motamedchaboki+K%22">Motamedchaboki K</searchLink>; Seer, Inc., Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hornburg+D%22">Hornburg D</searchLink>; Seer, Inc., Redwood City, CA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+TB%22">Johnson TB</searchLink>; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.<br /><searchLink fieldCode="AU" term="%22Swier+VJ%22">Swier VJ</searchLink>; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.<br /><searchLink fieldCode="AU" term="%22Weimer+JM%22">Weimer JM</searchLink>; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA.; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, USA.<br /><searchLink fieldCode="AU" term="%22Brudvig+JJ%22">Brudvig JJ</searchLink>; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA. jbrudvig@amicusrx.com.; Discovery Science, Amicus Therapeutics, Philadelphia, PA, USA. jbrudvig@amicusrx.com.; Department of Pediatrics, University of South Dakota Sanford School of Medicine, Vermillion, SD, USA. jbrudvig@amicusrx.com.
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  Data: <searchLink fieldCode="JN" term="%229918250414506676%22">Communications medicine</searchLink> [Commun Med (Lond)] 2026 Mar 03; Vol. 6 (1). <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Portfolio%22">Nature Portfolio </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918250414506676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2730-664X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222730664X%22">2730664X </searchLink><i>NLM ISO Abbreviation: </i>Commun Med (Lond) <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 03
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