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Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study.

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Title: Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study.
Authors: Corona A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Clarelli F; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pääkkönen K; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Harroud A; The Neuro (Montreal Neurological Institute-Hospital), Montréal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Department of Human Genetics, McGill University, Montréal, QC, Canada., Shchetynsky K; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Zollo A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Mingione A; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy., Sorosina M; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy., Mascia E; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy., Giordano A; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy., Rocca MA; Vita-Salute San Raffaele University, Milan, Italy., Piehl F; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, CMM L8:05, Stockholm, Sweden., Stridh P; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Hemmer B; Department of Neurology, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Goris A; Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain Institute, Leuven, Belgium., Dubois B; Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain Institute, Leuven, Belgium; Department of Neurology, University Hospitals, Leuven, Belgium., Søndergaard HB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark., Sellebjerg F; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark., D'alfonso S; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Harbo HF; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway., Olsson T; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Saarela J; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland., Priori A; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy; Clinical Neurology Unit, Department of Health Sciences, Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo, University of Milan, Milan, Italy., Filippi M; Vita-Salute San Raffaele University, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kockum I; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Esposito F; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Martinelli Boneschi F; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy; Clinical Neurology Unit, Department of Health Sciences, Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo, University of Milan, Milan, Italy.
Source: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2026 Jun; Vol. 32 (7), pp. 747-758. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: SAGE Publications Country of Publication: England NLM ID: 9509185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0970 (Electronic) Linking ISSN: 13524585 NLM ISO Abbreviation: Mult Scler Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study.
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  Data: <searchLink fieldCode="AU" term="%22Corona+A%22">Corona A</searchLink>; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Clarelli+F%22">Clarelli F</searchLink>; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pääkkönen+K%22">Pääkkönen K</searchLink>; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Harroud+A%22">Harroud A</searchLink>; The Neuro (Montreal Neurological Institute-Hospital), Montréal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Department of Human Genetics, McGill University, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Shchetynsky+K%22">Shchetynsky K</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Zollo+A%22">Zollo A</searchLink>; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mingione+A%22">Mingione A</searchLink>; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Sorosina+M%22">Sorosina M</searchLink>; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mascia+E%22">Mascia E</searchLink>; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+A%22">Giordano A</searchLink>; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rocca+MA%22">Rocca MA</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Piehl+F%22">Piehl F</searchLink>; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, CMM L8:05, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Stridh+P%22">Stridh P</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Hemmer+B%22">Hemmer B</searchLink>; Department of Neurology, School of Medicine, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Goris+A%22">Goris A</searchLink>; Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain Institute, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dubois+B%22">Dubois B</searchLink>; Laboratory for Neuroimmunology, Department of Neurosciences, KU Leuven Brain Institute, Leuven, Belgium; Department of Neurology, University Hospitals, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Søndergaard+HB%22">Søndergaard HB</searchLink>; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22Sellebjerg+F%22">Sellebjerg F</searchLink>; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark.<br /><searchLink fieldCode="AU" term="%22D'alfonso+S%22">D'alfonso S</searchLink>; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Harbo+HF%22">Harbo HF</searchLink>; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norway; Department of Neurology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Olsson+T%22">Olsson T</searchLink>; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Saarela+J%22">Saarela J</searchLink>; Institute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Priori+A%22">Priori A</searchLink>; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy; Clinical Neurology Unit, Department of Health Sciences, Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Filippi+M%22">Filippi M</searchLink>; Vita-Salute San Raffaele University, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Kockum+I%22">Kockum I</searchLink>; Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Esposito+F%22">Esposito F</searchLink>; Laboratory of Human Genetics of Neurological Disorders, IRCCS San Raffaele Scientific Institute, Milan, Italy; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Martinelli+Boneschi+F%22">Martinelli Boneschi F</searchLink>; Laboratory of Precision Medicine of Neurological Diseases, Department of Health Science, University of Milan, Milan, Italy; CRC 'Aldo Ravelli' for Experimental Brain Therapeutics, Department of Health Science, University of Milan, Milan, Italy; Clinical Neurology Unit, Department of Health Sciences, Azienda Socio-Sanitaria Territoriale Santi Paolo e Carlo, University of Milan, Milan, Italy.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22SAGE+Publications%22">SAGE Publications </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9509185 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1477-0970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213524585%22">13524585 </searchLink><i>NLM ISO Abbreviation: </i>Mult Scler <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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