Survival of patients with colorectal or pancreatic cancer who received UGT1A1 genotype-guided dosing of irinotecan in the Netherlands (2017-2024): a retrospective, multicentre cohort study.

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Title: Survival of patients with colorectal or pancreatic cancer who received UGT1A1 genotype-guided dosing of irinotecan in the Netherlands (2017-2024): a retrospective, multicentre cohort study.
Authors: Peeters SLJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands., Heersche N; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.; Department of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., Böhm D; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands., Böhringer S; Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands., Guiljam R; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands., Hulshof EC; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands., de Man FM; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands., de With M; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands.; Department of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., Joosse M; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Oomens G; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Wu QY; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands., Osman A; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands., Bins S; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands., van Hellemond IEG; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Haberkorn BCM; Department of Medical Oncology, Maasstad Hospital, Rotterdam, the Netherlands., Verschoor AJ; Department of Medical Oncology, Reinier de Graaf Gasthuis, Delft, the Netherlands., Wumkes ML; Department of Medical Oncology, Jeroen Bosch Hospital, 's Hertogenbosch, the Netherlands., van Schaik RHN; Department of Clinical Chemistry, Erasmus University Medical Centre, Rotterdam, the Netherlands., Thijs AM; Department of Medical Oncology, Catharina Hospital, Eindhoven, the Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands., Mathijssen RHJ; Department of Medical Oncology, Erasmus Medical Centre Cancer Institute, Rotterdam, the Netherlands., Deenen MJ; Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre Leiden, the Netherlands.
Source: The Lancet regional health. Europe [Lancet Reg Health Eur] 2026 Feb 23; Vol. 64, pp. 101629. Date of Electronic Publication: 2026 Feb 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: [Oxford] Country of Publication: England NLM ID: 101777707 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-7762 (Electronic) Linking ISSN: 26667762 NLM ISO Abbreviation: Lancet Reg Health Eur Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="JN" term="%22101777707%22">The Lancet regional health. Europe</searchLink> [Lancet Reg Health Eur] 2026 Feb 23; Vol. 64, pp. 101629. <i>Date of Electronic Publication: </i>2026 Feb 23 (<i>Print Publication: </i>2026).
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