Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.
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| Title: | Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. |
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| Authors: | Ganeshalingam AA; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., Uhrenholt N; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Research Unit for Clinical Psychopharmacology, Psychiatry West in Region Zealand, Slagelse, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark., Arnfred S; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Gæde P; Department of Internal Medicine, Geriatrics and Neurology, Næstved, Slagelse og Ringsted Sygehuse, Slagelse, Denmark.; IRS-Department of Regional Health Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark., Pedersen AK; OUH, OPEN-Open Patient Data Explorative Network (Odense), Odense, Denmark., Bilenberg N; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark., Frystyk J; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. |
| Source: | Diabetes care [Diabetes Care] 2026 May 01; Vol. 49 (5), pp. 800-807. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| FullText | Links: – Type: pdflink Text: Availability: 1 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41778920 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Ganeshalingam+AA%22">Ganeshalingam AA</searchLink>; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Uhrenholt+N%22">Uhrenholt N</searchLink>; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Research Unit for Clinical Psychopharmacology, Psychiatry West in Region Zealand, Slagelse, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark.<br /><searchLink fieldCode="AU" term="%22Arnfred+S%22">Arnfred S</searchLink>; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gæde+P%22">Gæde P</searchLink>; Department of Internal Medicine, Geriatrics and Neurology, Næstved, Slagelse og Ringsted Sygehuse, Slagelse, Denmark.; IRS-Department of Regional Health Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Pedersen+AK%22">Pedersen AK</searchLink>; OUH, OPEN-Open Patient Data Explorative Network (Odense), Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Bilenberg+N%22">Bilenberg N</searchLink>; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Frystyk+J%22">Frystyk J</searchLink>; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227805975%22">Diabetes care</searchLink> [Diabetes Care] 2026 May 01; Vol. 49 (5), pp. 800-807. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7805975 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1935-5548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201495992%22">01495992 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes Care <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41778920 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2337/dc25-2041 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 800 Titles: – TitleFull: Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ganeshalingam AA – PersonEntity: Name: NameFull: Uhrenholt N – PersonEntity: Name: NameFull: Arnfred S – PersonEntity: Name: NameFull: Gæde P – PersonEntity: Name: NameFull: Pedersen AK – PersonEntity: Name: NameFull: Bilenberg N – PersonEntity: Name: NameFull: Frystyk J IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May 01 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1935-5548 Numbering: – Type: volume Value: 49 – Type: issue Value: 5 Titles: – TitleFull: Diabetes care Type: main |
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