Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly.
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| Title: | Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. |
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| Authors: | Ganeshalingam AA; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark., Uhrenholt N; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Research Unit for Clinical Psychopharmacology, Psychiatry West in Region Zealand, Slagelse, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark., Arnfred S; Psychiatric Research Unit, Copenhagen University Hospital-Psychiatry Region Zealand, Slagelse, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Gæde P; Department of Internal Medicine, Geriatrics and Neurology, Næstved, Slagelse og Ringsted Sygehuse, Slagelse, Denmark.; IRS-Department of Regional Health Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark., Pedersen AK; OUH, OPEN-Open Patient Data Explorative Network (Odense), Odense, Denmark., Bilenberg N; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Child and Adolescent Psychiatry Odense, Mental Health Services in the Region of Southern Denmark, Odense, Denmark., Frystyk J; Endocrine Research Unit, Department of Endocrinology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. |
| Source: | Diabetes care [Diabetes Care] 2026 May 01; Vol. 49 (5), pp. 800-807. |
| Publication Type: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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