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Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases.

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Title: Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases.
Authors: Annapragada AV; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Foda ZH; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Orjuela H; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Norton C; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Koul S; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Niknafs N; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Short S; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Boyapati K; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Bartolomucci A; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Mathios D; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.; Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Noë M; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Cherry C; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Carey J; Delfi Diagnostics, Baltimore, MD 21231, USA., Leal A; Delfi Diagnostics, Baltimore, MD 21231, USA., Chesnick B; Delfi Diagnostics, Baltimore, MD 21231, USA., Dracopoli NC; Delfi Diagnostics, Baltimore, MD 21231, USA., Medina JE; Delfi Diagnostics, Baltimore, MD 21231, USA., Vulpescu NA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Bruhm DC; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Bacus S; Seq Biomarque LLC, Brea, CA 92821, USA., Adleff V; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Kim AK; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Baylin SB; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Kirk GD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA., Sorop A; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania., Iacob R; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania., Iacob S; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania., Gheorghe L; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania., Dima S; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania.; Genomics Research and Development Institute, 022328, Bucharest, Romania., Ramírez-Zea M; Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central American and Panama (INCAP), 01011, Guatemala City, Guatemala., McGlynn KA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA., Feltoft CL; Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, 2730, Herlev, Denmark., Johansen JS; Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, 2730, Herlev, Denmark., Groopman J; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Phallen J; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Scharpf RB; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA., Velculescu VE; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Mar 04; Vol. 18 (839), pp. eadw2603. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases.
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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Sorop+A%22">Sorop A</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Iacob+R%22">Iacob R</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Iacob+S%22">Iacob S</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Gheorghe+L%22">Gheorghe L</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Dima+S%22">Dima S</searchLink>; Center of Digestive Diseases and Liver Transplantation, Fundeni Clinical Institute, 022328, Bucharest, Romania.; Center of Excellence in Translational Medicine, Fundeni Clinical Institute, 022328, Bucharest, Romania.; University of Medicine and Pharmacy Carol Davila, 022328, Bucharest, Romania.; Genomics Research and Development Institute, 022328, Bucharest, Romania.<br /><searchLink fieldCode="AU" term="%22Ramírez-Zea+M%22">Ramírez-Zea M</searchLink>; Research Center for the Prevention of Chronic Diseases, Institute of Nutrition of Central American and Panama (INCAP), 01011, Guatemala City, Guatemala.<br /><searchLink fieldCode="AU" term="%22McGlynn+KA%22">McGlynn KA</searchLink>; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Feltoft+CL%22">Feltoft CL</searchLink>; Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, 2730, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Johansen+JS%22">Johansen JS</searchLink>; Department of Medicine, Copenhagen University Hospital-Herlev and Gentofte, 2730, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Groopman+J%22">Groopman J</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Phallen+J%22">Phallen J</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Scharpf+RB%22">Scharpf RB</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.<br /><searchLink fieldCode="AU" term="%22Velculescu+VE%22">Velculescu VE</searchLink>; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2026 Mar 04; Vol. 18 (839), pp. eadw2603. <i>Date of Electronic Publication: </i>2026 Mar 04.
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