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Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.

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Title: Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.
Authors: Satoeya N; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Zack SR; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Zoubi OA; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Umar S; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Burgos A; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Abdulrab S; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Zanotti B; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA., Volin MV; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA., Karam JA; Department of Orthopedic Surgery, University of Illinois College of Medicine, Chicago, IL, USA., Xia Y; Jesse Brown VA Medical Center, Chicago, IL, USA., Umali DC; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Arami S; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Al-Awqati M; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Chang HT; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., O'Neill LAJ; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland., Schett G; Department of Internal Medicine Rheumatology and Immunology Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Sweiss N; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA., Shahrara S; Jesse Brown VA Medical Center, Chicago, IL, USA. shahrara@uic.edu.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA. shahrara@uic.edu.
Source: Cellular & molecular immunology [Cell Mol Immunol] 2026 Apr; Vol. 23 (4), pp. 417-431. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Chinese Society of Immunology Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.
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  Data: <searchLink fieldCode="AU" term="%22Satoeya+N%22">Satoeya N</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zack+SR%22">Zack SR</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zoubi+OA%22">Zoubi OA</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Umar+S%22">Umar S</searchLink>; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Burgos+A%22">Burgos A</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Abdulrab+S%22">Abdulrab S</searchLink>; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zanotti+B%22">Zanotti B</searchLink>; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA.<br /><searchLink fieldCode="AU" term="%22Volin+MV%22">Volin MV</searchLink>; Department of Microbiology and Immunology, Midwestern University, Downers Grove, IL, USA.<br /><searchLink fieldCode="AU" term="%22Karam+JA%22">Karam JA</searchLink>; Department of Orthopedic Surgery, University of Illinois College of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Umali+DC%22">Umali DC</searchLink>; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Arami+S%22">Arami S</searchLink>; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Al-Awqati+M%22">Al-Awqati M</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chang+HT%22">Chang HT</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22O'Neill+LAJ%22">O'Neill LAJ</searchLink>; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Schett+G%22">Schett G</searchLink>; Department of Internal Medicine Rheumatology and Immunology Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie, Friedrich-Alexander Universität Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Sweiss+N%22">Sweiss N</searchLink>; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shahrara+S%22">Shahrara S</searchLink>; Jesse Brown VA Medical Center, Chicago, IL, USA. shahrara@uic.edu.; Department of Medicine, Division of Rheumatology, The University of Illinois Chicago, Chicago, IL, USA. shahrara@uic.edu.
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  Data: <searchLink fieldCode="JN" term="%22101242872%22">Cellular & molecular immunology</searchLink> [Cell Mol Immunol] 2026 Apr; Vol. 23 (4), pp. 417-431. <i>Date of Electronic Publication: </i>2026 Mar 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Chinese+Society+of+Immunology%22">Chinese Society of Immunology </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101242872 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-0226 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216727681%22">16727681 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41423-026-01395-x
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        Text: English
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