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Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.

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Title: Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.
Authors: Chen Y; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Liu Y; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Nguyen K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Wu J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Song S; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Lin K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Rodrigues PF; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Du S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Zhou C; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Xiong K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Bosch M; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Lin PB; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Khantakova D; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Wu S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Wu M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Yuede C; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Holtzman DM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
Source: Science (New York, N.Y.) [Science] 2026 Mar 05; Vol. 391 (6789), pp. eads3972. Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+K%22">Nguyen K</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Song+S%22">Song S</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+K%22">Lin K</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Rodrigues+PF%22">Rodrigues PF</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Du+S%22">Du S</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+K%22">Xiong K</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bosch+M%22">Bosch M</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lin+PB%22">Lin PB</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Khantakova+D%22">Khantakova D</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yuede+C%22">Yuede C</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Colonna+M%22">Colonna M</searchLink>; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.; Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, School of Medicine, St. Louis, MO, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 Mar 05; Vol. 391 (6789), pp. eads3972. <i>Date of Electronic Publication: </i>2026 Mar 05.
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