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Design, synthesis and biological evaluation of novel ursolic acid derivatives as potent anti-pancreatic cancer agents.

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Title: Design, synthesis and biological evaluation of novel ursolic acid derivatives as potent anti-pancreatic cancer agents.
Authors: Gatera T; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Zheng YD; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China., Liu JR; Department of Medicine, Northwest Minzu University, Lanzhou 730030, People's Republic of China., Hou YS; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China., Cheng ZF; College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, People's Republic of China., Bu XS; College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, People's Republic of China., Chang XL; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Zhang L; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Li CZ; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Zhu EJ; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China., Wang N; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China., Chai T; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China., Meng XH; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China., Wang XR; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China. Electronic address: wangxr@licp.cas.cn., Yang JL; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China. Electronic address: yangjl@licp.cas.cn.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2026 May; Vol. 136, pp. 118607. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design, synthesis and biological evaluation of novel ursolic acid derivatives as potent anti-pancreatic cancer agents.
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  Data: <searchLink fieldCode="AU" term="%22Gatera+T%22">Gatera T</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zheng+YD%22">Zheng YD</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Liu+JR%22">Liu JR</searchLink>; Department of Medicine, Northwest Minzu University, Lanzhou 730030, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Hou+YS%22">Hou YS</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Cheng+ZF%22">Cheng ZF</searchLink>; College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Bu+XS%22">Bu XS</searchLink>; College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chang+XL%22">Chang XL</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Li+CZ%22">Li CZ</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhu+EJ%22">Zhu EJ</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chai+T%22">Chai T</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Meng+XH%22">Meng XH</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wang+XR%22">Wang XR</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China. Electronic address: wangxr@licp.cas.cn.<br /><searchLink fieldCode="AU" term="%22Yang+JL%22">Yang JL</searchLink>; CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People's Republic of China. Electronic address: yangjl@licp.cas.cn.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2026 May; Vol. 136, pp. 118607. <i>Date of Electronic Publication: </i>2026 Feb 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9413298 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3391 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209680896%22">09680896 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.bmc.2026.118607
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      – Code: eng
        Text: English
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        StartPage: 118607
    Titles:
      – TitleFull: Design, synthesis and biological evaluation of novel ursolic acid derivatives as potent anti-pancreatic cancer agents.
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            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
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