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Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing.

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Title: Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing.
Authors: Chatla K; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Roper B; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Ayalew L; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Ko P; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Lippold S; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Doma M; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Camperi J; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
Source: Analytical chemistry [Anal Chem] 2026 Mar 17; Vol. 98 (10), pp. 7452-7461. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing.
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  Data: <searchLink fieldCode="AU" term="%22Chatla+K%22">Chatla K</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Roper+B%22">Roper B</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Ayalew+L%22">Ayalew L</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Ko+P%22">Ko P</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Lippold+S%22">Lippold S</searchLink>; Protein Analytical Chemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Doma+M%22">Doma M</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.<br /><searchLink fieldCode="AU" term="%22Camperi+J%22">Camperi J</searchLink>; Cell Therapy Engineering and Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
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  Data: <searchLink fieldCode="JN" term="%220370536%22">Analytical chemistry</searchLink> [Anal Chem] 2026 Mar 17; Vol. 98 (10), pp. 7452-7461. <i>Date of Electronic Publication: </i>2026 Mar 06.
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      – Type: doi
        Value: 10.1021/acs.analchem.5c06819
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      – Code: eng
        Text: English
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      – TitleFull: Assessing mRNA and sgRNA Quality for Cell and Gene Therapy Applications Using Nanopore Direct RNA Sequencing.
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              Text: 2026 Mar 17
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              Y: 2026
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