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Dynamic dual regulation of amphiregulin in liver pathophysiology: balancing regeneration and disease progression via the EGFR axis.

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Title: Dynamic dual regulation of amphiregulin in liver pathophysiology: balancing regeneration and disease progression via the EGFR axis.
Authors: Wang YL; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China., Zhou DJ; North Henan Medical University, Xinxiang, Henan, China., Wang QW; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China., Zhang Y; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China., Yang WJ; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China., Tan WJ; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China., Wang HY; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China., Chen XW; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.; Luoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China., Li SQ; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.
Source: Frontiers in medicine [Front Med (Lausanne)] 2026 Feb 18; Vol. 13, pp. 1697954. Date of Electronic Publication: 2026 Feb 18 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wang+YL%22">Wang YL</searchLink>; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+DJ%22">Zhou DJ</searchLink>; North Henan Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+QW%22">Wang QW</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Yang+WJ%22">Yang WJ</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Tan+WJ%22">Tan WJ</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+HY%22">Wang HY</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Chen+XW%22">Chen XW</searchLink>; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.; Luoyang Key Laboratory of Transplantation and Immunological Studies for Haematological Diseases, Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Li+SQ%22">Li SQ</searchLink>; The Molecular Medicine Key Laboratory of Liver Injury and Repair, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, Henan, China.; Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases, Luoyang, Henan, China.
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  Data: <searchLink fieldCode="JN" term="%22101648047%22">Frontiers in medicine</searchLink> [Front Med (Lausanne)] 2026 Feb 18; Vol. 13, pp. 1697954. <i>Date of Electronic Publication: </i>2026 Feb 18 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media+S%2EA%22">Frontiers Media S.A </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101648047 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>2296-858X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222296858X%22">2296858X </searchLink><i>NLM ISO Abbreviation: </i>Front Med (Lausanne) <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Feb 18
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