Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI).
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| Title: | Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI). |
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| Authors: | Shibuki T; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. tshibuki@east.ncc.go.jp.; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. tshibuki@east.ncc.go.jp., Yamashita R; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan., Hashimoto T; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Fujisawa T; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Imai M; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan., Yuda J; Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan., Kuwata T; Department of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan., Misumi T; Department of Data Science, National Cancer Center Hospital East, Chiba, Japan., Nakamura Y; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Bando H; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan., Kojima K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Tokioka S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Chiba I; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Nakaya N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Hozawa A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Koshiba S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Fuse N; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Saito S; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan., Shimizu R; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Park WY; GxD Inc., Kashiwa, Japan.; Translational Genomics Center, Samsung Medical Center, Seoul, Korea., Kinoshita K; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Yoshino T; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan. |
| Source: | International journal of clinical oncology [Int J Clin Oncol] 2026 May; Vol. 31 (5), pp. 843-850. Date of Electronic Publication: 2026 Mar 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 9616295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7772 (Electronic) Linking ISSN: 13419625 NLM ISO Abbreviation: Int J Clin Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41790338 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shibuki+T%22">Shibuki T</searchLink>; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan. tshibuki@east.ncc.go.jp.; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. tshibuki@east.ncc.go.jp.<br /><searchLink fieldCode="AU" term="%22Yamashita+R%22">Yamashita R</searchLink>; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Hashimoto+T%22">Hashimoto T</searchLink>; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Fujisawa+T%22">Fujisawa T</searchLink>; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Head and Neck Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Imai+M%22">Imai M</searchLink>; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.<br /><searchLink fieldCode="AU" term="%22Yuda+J%22">Yuda J</searchLink>; Department of Hematology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kuwata+T%22">Kuwata T</searchLink>; Department of Genetic Medicine and Services, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Misumi+T%22">Misumi T</searchLink>; Department of Data Science, National Cancer Center Hospital East, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Nakamura+Y%22">Nakamura Y</searchLink>; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Bando+H%22">Bando H</searchLink>; Department for the Promotion of Drug and Diagnostic Development, Division of Drug and Diagnostic Development Promotion, Translational Research Support Office, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.<br /><searchLink fieldCode="AU" term="%22Kojima+K%22">Kojima K</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Tokioka+S%22">Tokioka S</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Chiba+I%22">Chiba I</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Nakaya+N%22">Nakaya N</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Hozawa+A%22">Hozawa A</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Koshiba+S%22">Koshiba S</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Fuse+N%22">Fuse N</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Saito+S%22">Saito S</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+R%22">Shimizu R</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Park+WY%22">Park WY</searchLink>; GxD Inc., Kashiwa, Japan.; Translational Genomics Center, Samsung Medical Center, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Kinoshita+K%22">Kinoshita K</searchLink>; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshino+T%22">Yoshino T</searchLink>; Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229616295%22">International journal of clinical oncology</searchLink> [Int J Clin Oncol] 2026 May; Vol. 31 (5), pp. 843-850. <i>Date of Electronic Publication: </i>2026 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag+Tokyo%22">Springer-Verlag Tokyo </searchLink><i>Country of Publication: </i>Japan <i>NLM ID: </i>9616295 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1437-7772 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213419625%22">13419625 </searchLink><i>NLM ISO Abbreviation: </i>Int J Clin Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41790338 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10147-026-03001-6 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 843 Titles: – TitleFull: Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shibuki T – PersonEntity: Name: NameFull: Yamashita R – PersonEntity: Name: NameFull: Hashimoto T – PersonEntity: Name: NameFull: Fujisawa T – PersonEntity: Name: NameFull: Imai M – PersonEntity: Name: NameFull: Yuda J – PersonEntity: Name: NameFull: Kuwata T – PersonEntity: Name: NameFull: Misumi T – PersonEntity: Name: NameFull: Nakamura Y – PersonEntity: Name: NameFull: Bando H – PersonEntity: Name: NameFull: Kojima K – PersonEntity: Name: NameFull: Tokioka S – PersonEntity: Name: NameFull: Chiba I – PersonEntity: Name: NameFull: Nakaya N – PersonEntity: Name: NameFull: Hozawa A – PersonEntity: Name: NameFull: Koshiba S – PersonEntity: Name: NameFull: Fuse N – PersonEntity: Name: NameFull: Saito S – PersonEntity: Name: NameFull: Shimizu R – PersonEntity: Name: NameFull: Park WY – PersonEntity: Name: NameFull: Kinoshita K – PersonEntity: Name: NameFull: Yoshino T IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 May Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1437-7772 Numbering: – Type: volume Value: 31 – Type: issue Value: 5 Titles: – TitleFull: International journal of clinical oncology Type: main |
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