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Cytotoxic, genotoxic, and apoptotic effects of manganese nitrate on RAW264.7 macrophages via reactive oxygen species accumulation and mitochondrial injury.

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Title: Cytotoxic, genotoxic, and apoptotic effects of manganese nitrate on RAW264.7 macrophages via reactive oxygen species accumulation and mitochondrial injury.
Authors: Tsai PK; Department of Emergency Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical University, Taipei, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan., Wu SW; Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Internal Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan., Lee YJ; Department of Emergency Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan; Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan., Hsieh YT; Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan., Ho YC; Center for General Education, Chung Shan Medical University, Taichung, Taiwan., Lee SS; School of Public Health, Chung Shan Medical University, Taichung, Taiwan., Kuan YH; Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: kuanyh@csmu.edu.tw.
Source: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2026 Apr; Vol. 94, pp. 127852. Date of Electronic Publication: 2026 Feb 28.
Publication Type: Journal Article
Journal Info: Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cytotoxic, genotoxic, and apoptotic effects of manganese nitrate on RAW264.7 macrophages via reactive oxygen species accumulation and mitochondrial injury.
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  Data: <searchLink fieldCode="AU" term="%22Tsai+PK%22">Tsai PK</searchLink>; Department of Emergency Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan; Department of Emergency Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; Graduate Institute of Aerospace and Undersea Medicine, National Defense Medical University, Taipei, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+SW%22">Wu SW</searchLink>; Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Internal Medicine, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+YJ%22">Lee YJ</searchLink>; Department of Emergency Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan; Department of Nursing, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YT%22">Hsieh YT</searchLink>; Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ho+YC%22">Ho YC</searchLink>; Center for General Education, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+SS%22">Lee SS</searchLink>; School of Public Health, Chung Shan Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kuan+YH%22">Kuan YH</searchLink>; Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: kuanyh@csmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229508274%22">Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)</searchLink> [J Trace Elem Med Biol] 2026 Apr; Vol. 94, pp. 127852. <i>Date of Electronic Publication: </i>2026 Feb 28.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Gustav+Fisher%22">Gustav Fisher </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9508274 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1878-3252 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220946672X%22">0946672X </searchLink><i>NLM ISO Abbreviation: </i>J Trace Elem Med Biol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jtemb.2026.127852
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        Text: English
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              Text: 2026 Apr
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