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An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.

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Title: An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.
Authors: Warren A; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland., Holleran L; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland., Agartz I; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Andreassen OA; Department of Psychiatry, Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Oslo, Norway., Banaj N; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Cannon DM; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland., Corvin A; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland., Green M; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia., Gur R; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Hashimoto R; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan., Hong E; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA., Hoschl C; National Institute of Mental Health, Klecany, Czechia., Kochunov P; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; University of Maryland Center for Brain Imaging Research, University of Maryland, Baltimore, MD, USA., Lawrie SM; Department of Psychiatry, University of Edinburgh, Edinburgh, UK., McDonald C; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland., Morris D; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland., Mothersill D; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland., Neilson E; Department of Psychiatry, University of Edinburgh, Edinburgh, UK., Pantelis C; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia., Piras F; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Rasser PE; Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, Newcastle, NSW, Australia., Roalf D; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan., Satterthwaite TD; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Schall U; Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia., Sim K; West Region, Institute of Mental Health, Singapore, Singapore., Skoch A; National Institute of Mental Health, Klecany, Czechia., Spalletta G; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy., Spaniel F; National Institute of Mental Health, Klecany, Czechia., Thomopoulos S; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Tomecek D; National Institute of Mental Health, Klecany, Czechia., Zalesky A; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia., Thompson PM; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Jahanshad N; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Turner JA; Department of Psychiatry & Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., van Erp TGM; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA., Donohoe G; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland. gary.donohoe@universityofgalway.ie.
Corporate Authors: ENIGMA Consortium Schizophrenia Working Group
Source: Schizophrenia (Heidelberg, Germany) [Schizophrenia (Heidelb)] 2026 Mar 06; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Limited Country of Publication: Germany NLM ID: 9918367987006676 Publication Model: Electronic Cited Medium: Internet ISSN: 2754-6993 (Electronic) Linking ISSN: 27546993 NLM ISO Abbreviation: Schizophrenia (Heidelb) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.
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  Data: <searchLink fieldCode="AU" term="%22Warren+A%22">Warren A</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Holleran+L%22">Holleran L</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Agartz+I%22">Agartz I</searchLink>; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Andreassen+OA%22">Andreassen OA</searchLink>; Department of Psychiatry, Ullevål University Hospital and Institute of Psychiatry, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Banaj+N%22">Banaj N</searchLink>; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cannon+DM%22">Cannon DM</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Corvin+A%22">Corvin A</searchLink>; Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Green+M%22">Green M</searchLink>; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gur+R%22">Gur R</searchLink>; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hashimoto+R%22">Hashimoto R</searchLink>; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Hong+E%22">Hong E</searchLink>; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hoschl+C%22">Hoschl C</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Kochunov+P%22">Kochunov P</searchLink>; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.; University of Maryland Center for Brain Imaging Research, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lawrie+SM%22">Lawrie SM</searchLink>; Department of Psychiatry, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22McDonald+C%22">McDonald C</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Morris+D%22">Morris D</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Mothersill+D%22">Mothersill D</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland.; Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Neilson+E%22">Neilson E</searchLink>; Department of Psychiatry, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Pantelis+C%22">Pantelis C</searchLink>; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Piras+F%22">Piras F</searchLink>; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Rasser+PE%22">Rasser PE</searchLink>; Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.; Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Callaghan, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Roalf+D%22">Roalf D</searchLink>; Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Satterthwaite+TD%22">Satterthwaite TD</searchLink>; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Schall+U%22">Schall U</searchLink>; Centre for Brain & Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sim+K%22">Sim K</searchLink>; West Region, Institute of Mental Health, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Skoch+A%22">Skoch A</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Spalletta+G%22">Spalletta G</searchLink>; Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Spaniel+F%22">Spaniel F</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Thomopoulos+S%22">Thomopoulos S</searchLink>; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tomecek+D%22">Tomecek D</searchLink>; National Institute of Mental Health, Klecany, Czechia.<br /><searchLink fieldCode="AU" term="%22Zalesky+A%22">Zalesky A</searchLink>; Systems Lab, Departments of Psychiatry & Biomedical Engineering, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thompson+PM%22">Thompson PM</searchLink>; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jahanshad+N%22">Jahanshad N</searchLink>; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Turner+JA%22">Turner JA</searchLink>; Department of Psychiatry & Behavioral Health, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22van+Erp+TGM%22">van Erp TGM</searchLink>; Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Donohoe+G%22">Donohoe G</searchLink>; School of Psychology, Centre for Neuroimaging, Cognition and Genomics (NICOG), & Galway Neuroscience Centre, University of Galway, Galway, Ireland. gary.donohoe@universityofgalway.ie.
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