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Engineering tumor-specific interferon-alpha-Nivolumab pro-immunocytokine for enhanced melanoma immunotherapy.

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Title: Engineering tumor-specific interferon-alpha-Nivolumab pro-immunocytokine for enhanced melanoma immunotherapy.
Authors: Chao SW; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: nikezhou11@gmail.com., Huang BC; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: ha2008240@gmail.com., Hong ST; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: gwu714@gmail.com., Ho KW; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: Kevin79512003@gmail.com., Wang YT; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: c00jsw00@gmail.com., Huang YT; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: yuting911129@gmail.com., Li CT; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: seer48994@gmail.com., Chen SJ; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: muriel910916@gmail.com., Wang HR; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: redperson612@gmail.com., Huang YJ; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: isu9941025a@gmail.com., Hsu YH; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: R980009@kmu.edu.tw., Lin WW; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: wwlin0627@kmu.edu.tw., Chen CY; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: ccy77015@gmail.com., Chuang CH; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: a4132600@gmail.com.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Apr; Vol. 354, pp. 151271. Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineering tumor-specific interferon-alpha-Nivolumab pro-immunocytokine for enhanced melanoma immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Chao+SW%22">Chao SW</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: nikezhou11@gmail.com.<br /><searchLink fieldCode="AU" term="%22Huang+BC%22">Huang BC</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Surgery, Faculty of Medicine College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: ha2008240@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hong+ST%22">Hong ST</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: gwu714@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ho+KW%22">Ho KW</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: Kevin79512003@gmail.com.<br /><searchLink fieldCode="AU" term="%22Wang+YT%22">Wang YT</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: c00jsw00@gmail.com.<br /><searchLink fieldCode="AU" term="%22Huang+YT%22">Huang YT</searchLink>; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: yuting911129@gmail.com.<br /><searchLink fieldCode="AU" term="%22Li+CT%22">Li CT</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: seer48994@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chen+SJ%22">Chen SJ</searchLink>; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: muriel910916@gmail.com.<br /><searchLink fieldCode="AU" term="%22Wang+HR%22">Wang HR</searchLink>; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: redperson612@gmail.com.<br /><searchLink fieldCode="AU" term="%22Huang+YJ%22">Huang YJ</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: isu9941025a@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hsu+YH%22">Hsu YH</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: R980009@kmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Lin+WW%22">Lin WW</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: wwlin0627@kmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Biochemistry, School of Post Baccalaureate Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: ccy77015@gmail.com.<br /><searchLink fieldCode="AU" term="%22Chuang+CH%22">Chuang CH</searchLink>; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Drug Development and Value Creation Research Center, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; Department of Medical Laboratory Science and Biotechnology, college of Health Sciences, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan. Electronic address: a4132600@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Apr; Vol. 354, pp. 151271. <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7909578 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418130%22">01418130 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Macromol <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.ijbiomac.2026.151271
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      – Code: eng
        Text: English
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        StartPage: 151271
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      – TitleFull: Engineering tumor-specific interferon-alpha-Nivolumab pro-immunocytokine for enhanced melanoma immunotherapy.
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              Text: 2026 Apr
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